Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

by Heiner, Monika , Glaser, Rolf David , Vadász, István , Gattenlöhner, Stefan , Vazquez-Armendariz, Ana Ivonne , Alexopoulos, Ioannis , Selvakumar, Balachandar , Ferrero, Maximiliano Ruben , Malainou, Christina , Weiss, Astrid , Seeger, Werner , Herold, Susanne , Pervizaj-Oruqaj, Learta , Morty, Rory Edward , Witte, Biruta , Schermuly, Ralph Theo , Wilhelm, Jochen , Bartkuhn, Marek

in 13 / 13/105 / 13/106 / 13/2 / 13/31 / 13/51 / 14/19 / 14/34 / 14/63 / 38/61 / 38/77 / 38/91 / 631/250/2504/342/1927 / 631/250/254 / 64/60 / 82/29 / 96/1 / 96/21 / Animals / Bone marrow / Cell proliferation / Colleges & universities / Epithelial cells / Epithelium / Female / Gene targeting / Genes / Homeostasis / Hospitals / Humanities and Social Sciences / Humans / Infections / Inflammation / Influenza / Influenza A / Influenza A virus / Influenza, Human / Internal medicine / Lung / Lung diseases / Lungs / Macrophages / Macrophages, Alveolar / Mice / multidisciplinary / Organoids / Placenta / Pneumonia / Pneumonia, Viral / Pregnancy / Science / Science (multidisciplinary) / Stem cells / Trachea / Transcriptomics / Viruses

2024

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

2024

Confirm

Do you wish to request the book?

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

2024

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

Heiner, Monika,

Glaser, Rolf David,

Vadász, István,

Gattenlöhner, Stefan,

Vazquez-Armendariz, Ana Ivonne,

Alexopoulos, Ioannis,

Selvakumar, Balachandar,

Ferrero, Maximiliano Ruben,

Malainou, Christina,

Weiss, Astrid,

Seeger, Werner,

Herold, Susanne,

Pervizaj-Oruqaj, Learta,

Morty, Rory Edward,

Witte, Biruta,

Schermuly, Ralph Theo,

Wilhelm, Jochen,

Bartkuhn, Marek

2024

Overview

Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the inflamed lung. Combining high-dimensional single-cell transcriptomics with complex lung organoid modeling, in vivo adoptive cell transfer, and BMDM-specific gene targeting, we found that transitioning (“regenerative”) BMDM and TR-AM highly express Placenta-expressed transcript 1 (Plet1). We reveal that Plet1 is released from alveolar macrophages, and acts as important mediator of macrophage-epithelial cross-talk during lung repair by inducing proliferation of alveolar epithelial cells and re-sealing of the epithelial barrier. Intratracheal administration of recombinant Plet1 early in the disease course attenuated viral lung injury and rescued mice from otherwise fatal disease, highlighting its therapeutic potential. Influenza virus infection causes injury to the lung. Here, Pervizaj-Oruqaj et al. show that Plet1 expressed by lung macrophages promotes epithelial repair by boosting epithelial cell proliferation and barrier function.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 13/105

/ 13/106

/ 13/2

/ 13/31

/ 13/51

/ 14/19

/ 14/34