Asset Details
Do you wish to reserve the book?
Muscle spindle afferent neurons preferentially degenerate with aging
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Muscle spindle afferent neurons preferentially degenerate with aging
Do you wish to request the book?
Muscle spindle afferent neurons preferentially degenerate with aging
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Muscle spindle afferent neurons preferentially degenerate with aging
2025
Overview
Muscle spindles sense changes in muscle length and transmit them to the central nervous system. Proprioception is essential for gait and postural maintenance, the abnormality of which has been linked to gait disorders and the risk of falling in older adults. However, the effects of aging on the muscle spindle structure remain nebulous. This study investigated age-related structural changes in the muscle spindles (from the equator to the polar) in the soleus and extensor digitorum longus (EDL) muscles of young, middle-aged, and aged mice. The findings indicated that the shape of the annulospiral endings of the sensory neurons began to deteriorate in middle-aged compared with young mice and was further exacerbated in aged mice. These changes were particularly pronounced in the nuclear bag fibers, whereas no significant age-related changes were observed in the intrafusal fibers or capsules. A decline in gait function due to changes in weight-bearing and weight-shifting in aged mice was also observed, suggesting that the deterioration of proprioceptive sensory neurons that innervate the nuclear bag fiber responsible for dynamic sensitivity prevents proper coordinated movement and contributes to movement disorders in aged animals including humans, together with the functional decline of extrafusal fibers.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Aging
/ Animals
/ Equator
/ Gait
/ Humanities and Social Sciences
/ Male
/ Mice
/ Muscle Spindles - innervation
/ Muscle, Skeletal - innervation
/ Muscle, Skeletal - pathology
/ Muscles
/ Neurons
/ Neurons, Afferent - pathology
/ Neurons, Afferent - physiology
/ Proprioceptive sensory neuron
/ Science
