Asset Details
Do you wish to reserve the book?
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
Do you wish to request the book?
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
2018
Overview
Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine, that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a
MYB
expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Female
/ Gene Expression Regulation, Neoplastic
/ Humans
/ Medicine
/ Mice
/ Monocyte chemoattractant protein 1
/ Neoplasm Recurrence, Local - genetics
/ Neoplasm Recurrence, Local - metabolism
/ Neoplasm Recurrence, Local - pathology
/ Oncology
/ Proto-Oncogene Proteins c-myb - genetics
/ Proto-Oncogene Proteins c-myb - metabolism
/ Stroma
/ Tumors
