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Autosomal gsdf acts as a male sex initiator in the fish medaka

by Hong, Yunhan , Li, Mingyou , Laboratory of Bioresources ; National Institute for Basic Biology [Okazaki] , Zhu, Feng , This work was supported by grants to Y.H. from the National Research Foundation Singapore (NRF-CRP7-2010-03) and to M.L. from the National Natural Science Foundation of China and the Shanghai Universities First-Class Disciplines Project of Fisheries and by scholarship to X.Z. and F.Z. from the National University of Singapore , Liu, Qizhi , Zhang, Xi , Herpin, Amaury , Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique) , Naruse, Kiyoshi , Nagahama, Yoshitaka , Li, Jiale , Department of Biological Sciences ; National University of Singapore (NUS) , Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources of Ministry of Education and College of Fisheries and Life Sciences ; Shanghai Ocean University , South Ehime

in 13/31 / 14/19 / 38/109 / 38/32 / 38/77 / 38/90 / 38/91 / 45/29 / 45/41 / 631/208/135 / 631/208/200 / Adults / Animals / Eggs / Evolutionary genetics / Female / Females / Fish / Fisheries / Gene Deletion / Gene Expression Regulation, Developmental / Genes / Genomics / Genotype & phenotype / Gonads - embryology / Gonads - metabolism / Humanities and Social Sciences / Life Sciences / Male / Males / Mammals / Molecular modelling / multidisciplinary / Mutation / Oryzias - genetics / Phenotype / Science / Sex / Sex Determination Processes - genetics / Sperm / Testes / Transcription / Y Chromosome

2016

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2016

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2016

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Journal Article

Autosomal gsdf acts as a male sex initiator in the fish medaka

Hong, Yunhan,

Li, Mingyou,

Laboratory of Bioresources ; National Institute for Basic Biology [Okazaki],

Zhu, Feng,

This work was supported by grants to Y.H. from the National Research Foundation Singapore (NRF-CRP7-2010-03) and to M.L. from the National Natural Science Foundation of China and the Shanghai Universities First-Class Disciplines Project of Fisheries and by scholarship to X.Z. and F.Z. from the National University of Singapore,

Liu, Qizhi,

Zhang, Xi,

Herpin, Amaury,

Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique),

Naruse, Kiyoshi,

Nagahama, Yoshitaka,

Li, Jiale,

Department of Biological Sciences ; National University of Singapore (NUS),

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources of Ministry of Education and College of Fisheries and Life Sciences ; Shanghai Ocean University,

South Ehime

2016

Overview

Sex is pivotal for reproduction, healthcare and evolution. In the fish medaka, the Y-chromosomal dmy (also dmrt1bY) serves the sex determiner, which activates dmrt1 for male sex maintenance. However, how dmy makes the male decision via initiating testicular differentiation has remained unknown. Here we report that autosomal gsdf serves a male sex initiator. Gene addition and deletion revealed that gsdf was necessary and sufficient for maleness via initiating testicular differentiation. We show that gsdf transcription is activated directly by dmy. These results establish the autosomal gsdf as the first male sex initiator. We propose that dmy determines maleness through activating gsdf and dmrt1 without its own participation in developmental processes of sex initiation and maintenance. gsdf may easily become a sex determiner or other autosomal genes can be recruited as new sex determiners to initiate gsdf expression. Our findings offer new insights into molecular mechanisms underlying sex development and evolution of sex-controlling genes in vertebrates.

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Publisher

Nature Publishing Group,CCSD,Nature Publishing Group UK

Subject

13/31

/ 14/19

/ 38/109

/ 38/32

/ 38/77

/ 38/90

/ 38/91