Asset Details
Do you wish to reserve the book?
RRM1-induced metastasis suppression through PTEN-regulated pathways
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
RRM1-induced metastasis suppression through PTEN-regulated pathways
Do you wish to request the book?
RRM1-induced metastasis suppression through PTEN-regulated pathways
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
RRM1-induced metastasis suppression through PTEN-regulated pathways
2003
Overview
Lung cancer is the leading cause of cancer-related mortality in the United States. Only 15% of patients with this disease survive 5 years or longer. Early metastatic spread is the single most important reason for this poor outcome. The survival of patients with pathological stage I disease, that is, no evidence for metastatic spread, and molecular aberrations on chromosome 11p15.5 is equal to that of patients with stage II disease, that is, metastatic spread to hilar lymph nodes.
RRM1
is a gene in this region, and it is haploinsufficient in at least 34% stage I patients. Here, we show that overexpression of
RRM1
in human and mouse lung cancer cell lines induced
PTEN
expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model. Increased
PTEN
expression was required for the
RRM1
-induced suppression of cell motility and FAK phosphorylation. We conclude that
RRM1
functions as a metastasis suppressor gene through induction of
PTEN
expression.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Classical genetics, quantitative genetics, hybrids
/ Female
/ Focal Adhesion Protein-Tyrosine Kinases
/ Fundamental and applied biological sciences. Psychology
/ Genetics of eukaryotes. Biological and molecular evolution
/ Human
/ Humans
/ Kinases
/ Medicine
/ Mice
/ Neoplasm Metastasis - prevention & control
/ Oncology
/ Phosphoric Monoester Hydrolases - biosynthesis
/ Protein-Tyrosine Kinases - metabolism
/ Proteins
