Asset Details
Do you wish to reserve the book?
Ovulation: Parallels With Inflammatory Processes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Ovulation: Parallels With Inflammatory Processes
Do you wish to request the book?
Ovulation: Parallels With Inflammatory Processes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Ovulation: Parallels With Inflammatory Processes
2019
Overview
Abstract
The midcycle surge of LH sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes. These mediators, in turn, activate both nonimmune ovarian cells as well as resident immune cells within the ovary; additional immune cells are also attracted to the ovary. Collectively, these cells regulate proteolytic pathways to reorganize the follicular stroma, disrupt the granulosa cell basal lamina, and facilitate invasion of vascular endothelial cells. LH-induced mediators initiate cumulus expansion and cumulus oocyte complex detachment, whereas the follicular apex undergoes extensive extracellular matrix remodeling and a loss of the surface epithelium. The remainder of the follicle undergoes rapid angiogenesis and functional differentiation of granulosa and theca cells. Ultimately, these functional and structural changes culminate in follicular rupture and oocyte release. Throughout the ovulatory process, the importance of inflammatory responses is highlighted by the commonalities and similarities between many of these events associated with ovulation and inflammation. However, ovulation includes processes that are distinct from inflammation, such as regulation of steroid action, oocyte maturation, and the eventual release of the oocyte. This review focuses on the commonalities between inflammatory responses and the process of ovulation.
Publisher
Endocrine Society,Copyright Oxford University Press,Oxford University Press
Subject
/ 1986
/ 1987
/ 1988
/ 1989
/ 1990
/ Cascades
/ Cellular signal transduction
/ Female
/ gen sjf
/ Gynaecology, Obstetrics and Reproductive Medicine
/ Gynekologi, obstetrik och reproduktionsmedicin
/ hennin l
/ Humans
/ iowo ma
/ journal of biological chemistry
/ journal of cardiovascular pharmacology
/ journal of physiology-london
/ Luteinizing Hormone - metabolism
/ p274
/ p366
/ p589
/ p597
/ p6972
/ p76
/ Reviews
/ Rupture
/ Steroids
/ Stroma
/ Structure-function relationships
/ Theca
/ v10
/ v157
/ v261
/ v52
/ v54
/ x rh
