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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
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Journal Article
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
2020
Overview
For a One-Health investigation of antimicrobial resistance (AMR) in
Enterococcus
spp., isolates from humans and beef cattle along with abattoirs, manured fields, natural streams, and wastewater from both urban and cattle feedlot sources were collected over two years. Species identification of
Enterococcus
revealed distinct associations across the continuum. Of the 8430 isolates collected,
Enterococcus faecium
and
Enterococcus faecalis
were the main species in urban wastewater (90%) and clinical human isolates (99%);
Enterococcus hirae
predominated in cattle (92%) and feedlot catch-basins (60%), whereas natural streams harbored environmental
Enterococcus
spp. Whole-genome sequencing of
E. faecalis
(n = 366 isolates) and
E. faecium
(n = 342 isolates), revealed source clustering of isolates, indicative of distinct adaptation to their respective environments. Phenotypic resistance to tetracyclines and macrolides encoded by
tet(M)
and
erm(B)
respectively, was prevalent among
Enterococcus
spp. regardless of source. For
E. faecium
from cattle, resistance to β-lactams and quinolones was observed among 3% and 8% of isolates respectively, compared to 76% and 70% of human clinical isolates. Clinical vancomycin-resistant
E. faecium
exhibited high rates of multi-drug resistance, with resistance to all β-lactam, macrolides, and quinolones tested. Differences in the AMR profiles among isolates reflected antimicrobial use practices in each sector of the One-Health continuum.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Anti-Bacterial Agents - pharmacology
/ beta-Lactam Resistance - genetics
/ Cattle
/ Drug Resistance, Bacterial - genetics
/ Enterococcus - pathogenicity
/ Enterococcus faecalis - drug effects
/ Enterococcus faecalis - genetics
/ Enterococcus faecalis - pathogenicity
/ Enterococcus faecium - drug effects
/ Enterococcus faecium - genetics
/ Enterococcus faecium - pathogenicity
/ Feedlots
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Science
/ Species
/ Streams
