Asset Details
Do you wish to reserve the book?
Critical Roles of the Guanylyl Cyclase B Receptor in Endochondral Ossification and Development of Female Reproductive Organs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Critical Roles of the Guanylyl Cyclase B Receptor in Endochondral Ossification and Development of Female Reproductive Organs
Do you wish to request the book?
Critical Roles of the Guanylyl Cyclase B Receptor in Endochondral Ossification and Development of Female Reproductive Organs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Critical Roles of the Guanylyl Cyclase B Receptor in Endochondral Ossification and Development of Female Reproductive Organs
2004
Overview
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking guanylyl cyclase B through gene targeting. Expression of the receptor mRNA in tissues such as bone and female reproductive organs was evident, and significant phenotypes associated with each of these tissues were apparent in null mice. A dramatic impairment of endochondral ossification and an attenuation of longitudinal vertebra or limb-bone growth were seen in null animals. C-type natriuretic peptide-dependent increases of guanylyl cyclase B activity, but not basal enzyme activity, appeared to be required for the progression of endochondral ossification. Female mice were infertile, but male mice were not. This result was due to the failure of the female reproductive tract to develop. Thus, the guanylyl cyclase B receptor is critical for the development of both bone and female reproductive organs.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Bones
/ Extremities - growth & development
/ Female
/ Females
/ Genitalia, Female - growth & development
/ Guanylate Cyclase - genetics
/ Guanylate Cyclase - physiology
/ Mice
/ Natriuretic Peptide, C-Type - pharmacology
/ Peptides
/ Receptors, Atrial Natriuretic Factor - genetics
/ Receptors, Atrial Natriuretic Factor - physiology
/ Spine - growth & development
/ Uterus
/ Women
