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Generation of a Synthetic Memory Trace
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Journal Article
Generation of a Synthetic Memory Trace
2012
Overview
We investigated the effect of activating a competing, artificially generated, neural representation on encoding of contextual fear memory in mice. We used a c-fos-based transgenic approach to introduce the hM₃D q DREADD receptor (designer receptor exclusively activated by designer drug) into neurons naturally activated by sensory experience. Neural activity could then be specifically and inducibly increased in the hM₃D q -expressing neurons by an exogenous ligand. When an ensemble of neurons for one context (ctxA) was artificially activated during conditioning in a distinct second context (ctxB), mice formed a hybrid memory representation. Reactivation of the artificially stimulated network within the conditioning context was required for retrieval of the memory, and the memory was specific for the spatial pattern of neurons artificially activated during learning. Similar stimulation impaired recall when not part of the initial conditioning.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Brain
/ CA1 Region, Hippocampal - physiopathology
/ Clozapine - analogs & derivatives
/ Cues
/ Drugs
/ Fear
/ Freezing
/ Fundamental and applied biological sciences. Psychology
/ genetically modified organisms
/ hybrids
/ Learning
/ ligands
/ Memory
/ Mice
/ Neurons
/ Receptor, Muscarinic M3 - genetics
/ Receptor, Muscarinic M3 - metabolism
/ Rodents
