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Membrane protein-regulated networks across human cancers
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Journal Article
Membrane protein-regulated networks across human cancers
2019
Overview
Alterations in membrane proteins (MPs) and their regulated pathways have been established as cancer hallmarks and extensively targeted in clinical applications. However, the analysis of MP-interacting proteins and downstream pathways across human malignancies remains challenging. Here, we present a systematically integrated method to generate a resource of cancer membrane protein-regulated networks (CaMPNets), containing 63,746 high-confidence protein–protein interactions (PPIs) for 1962 MPs, using expression profiles from 5922 tumors with overall survival outcomes across 15 human cancers. Comprehensive analysis of CaMPNets links MP partner communities and regulated pathways to provide MP-based gene sets for identifying prognostic biomarkers and druggable targets. For example, we identify CHRNA9 with 12 PPIs (e.g., ERBB2) can be a therapeutic target and find its anti-metastasis agent, bupropion, for treatment in nicotine-induced breast cancer. This resource is a study to systematically integrate MP interactions, genomics, and clinical outcomes for helping illuminate cancer-wide atlas and prognostic landscapes in tumor homo/heterogeneity.
Membrane proteins have been implicated in cancers, but studying the downstream effects of their perturbation remains challenging. Here, the authors map the membrane protein-regulated network of 15 cancers, a resource for prognostic biomarker development and druggable target identification.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/33
/ 14/5
/ 38
/ 38/61
/ 38/77
/ 42/41
/ 64/60
/ Animals
/ Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ Biomarkers, Tumor - antagonists & inhibitors
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Cancer
/ Female
/ Gene Expression Regulation, Neoplastic - drug effects
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Nicotine
/ Nicotinic Antagonists - pharmacology
/ Nicotinic Antagonists - therapeutic use
/ Protein Interaction Mapping - methods
/ Protein Interaction Maps - drug effects
/ Protein Interaction Maps - genetics
/ Proteins
/ Receptors, Nicotinic - genetics
/ Receptors, Nicotinic - metabolism
/ Science
/ Tumors
