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Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
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Journal Article
Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
2018
Overview
Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms regulating expansion and fate of pre-existing SMCs in atherosclerotic plaques remain poorly defined. Here we show that multiple SMC progenitors mix to form the aorta during development. In contrast, during atherogenesis, a single SMC gives rise to the smooth muscle-derived cells that initially coat the cap of atherosclerotic plaques. Subsequently, highly proliferative cap cells invade the plaque core, comprising the majority of plaque cells. Reduction of integrin β3 (Itgb3) levels in SMCs induces toll-like receptor 4 expression and thereby enhances Cd36 levels and cholesterol-induced transdifferentiation to a macrophage-like phenotype. Global
Itgb3
deletion or transplantation of
Itgb3
(−/−)
bone marrow results in recruitment of multiple pre-existing SMCs into plaques. Conditioned medium from Itgb3-silenced macrophages enhances SMC proliferation and migration. Together, our results suggest SMC contribution to atherogenesis is regulated by integrin β3-mediated pathways in both SMCs and bone marrow-derived cells.
Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/109
/ 13/31
/ 13/51
/ 13/89
/ 14/1
/ 14/19
/ 14/63
/ 38/1
/ 38/35
/ 38/77
/ 64/110
/ 82/51
/ Animals
/ Aorta
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mice
/ Muscle, Smooth, Vascular - cytology
/ Muscles
/ Myocytes, Smooth Muscle - metabolism
/ Myocytes, Smooth Muscle - pathology
/ Plaque, Atherosclerotic - pathology
/ Plaque, Atherosclerotic - surgery
/ Plaques
/ Science
