Asset Details
Do you wish to reserve the book?
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Do you wish to request the book?
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
2017
Overview
Cryptococcus neoformans
is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in
C
.
neoformans
infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice. Gal-3-deficient mice are more susceptible to cryptococcosis than WT animals, as demonstrated by the higher fungal burden and lower animal survival. In vitro experiments show that Gal-3 inhibits fungal growth and exerts a direct lytic effect on
C
.
neoformans
extracellular vesicles (EVs). Our results indicate a direct role for Gal-3 in antifungal immunity whereby this molecule affects the outcome of
C
.
neoformans
infection by inhibiting fungal growth and reducing EV stability, which in turn could benefit the host.
The protein Galectin-3 modulates host immunity and plays roles during infections. Here, Almeida et al. show that this protein contributes to host defence against infection with the fungal pathogen
Cryptococcus neoformans
by inhibiting fungal growth and inducing lysis of fungal extracellular vesicles.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Antifungal Agents - immunology
/ Antifungal Agents - pharmacology
/ Bacterial Capsules - drug effects
/ Brain
/ Cryptococcosis - drug therapy
/ Cryptococcosis - microbiology
/ Cryptococcus neoformans - drug effects
/ Cryptococcus neoformans - growth & development
/ Cryptococcus neoformans - immunology
/ Fungi
/ Humanities and Social Sciences
/ Humans
/ Immunity
/ Lungs
/ Male
/ Mice
/ Rodents
/ Science
/ Spleen
