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Pre-clinical modeling of cutaneous melanoma
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Pre-clinical modeling of cutaneous melanoma
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Journal Article
Pre-clinical modeling of cutaneous melanoma
2020
Overview
Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.
Despite the new targeted and immunotherapies for metastatic melanoma, several patients show therapeutic plateau. Here, the authors review the current pre-clinical models of cutaneous melanoma and discuss their strengths and limitations that may help with overcoming therapeutic plateau.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 64/60
/ 96/95
/ Animals
/ Antinematodal Agents - pharmacology
/ Antinematodal Agents - therapeutic use
/ Biomarkers, Tumor - antagonists & inhibitors
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Cell Proliferation - drug effects
/ Humanities and Social Sciences
/ Humans
/ Melanoma
/ Mice
/ Review
/ Science
/ Skin Neoplasms - drug therapy
/ Therapy
