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Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae
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Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae
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Journal Article
Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae
2023
Overview
Our previous studies have shown that high alcohol-producing
Klebsiella pneumoniae
(HiAlc
Kpn
) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). Considering antimicrobial resistance of
K. pneumoniae
and dysbacteriosis caused by antibiotics, phage therapy might have potential in treatment of HiAlc
Kpn
-induced NAFLD, because of the specificity targeting the bacteria. Here, we clarified the effectiveness of phage therapy in male mice with HiAlc
Kpn
-induced steatohepatitis. Comprehensive investigations including transcriptomes and metabolomes revealed that treatment with HiAlc
Kpn
-specific phage was able to alleviate steatohepatitis caused by HiAlc
Kpn
, including hepatic dysfunction and expression of cytokines and lipogenic genes. In contrast, such treatment did not cause significantly pathological changes, either in functions of liver and kidney, or in components of gut microbiota. In addition to reducing alcohol attack, phage therapy also regulated inflammation, and lipid and carbohydrate metabolism. Our data suggest that phage therapy targeting gut microbiota is an alternative to antibiotics, with potential efficacy and safety, at least in HiAlc
Kpn
-caused NAFLD.
Previous studies have shown that high alcohol-producing
Klebsiella pneumoniae
(HiAlc
Kpn
) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). Here, the authors show the effectiveness of phage in mice with HiAlc
Kpn
-induced NAFLD indicating phage therapy targeting gut microbiota may be an alternative to antibiotics, with potential efficacy and safety.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ 45/91
/ Alcohol
/ Alcohols
/ Animals
/ Anti-Bacterial Agents - metabolism
/ Anti-Bacterial Agents - therapeutic use
/ Humanities and Social Sciences
/ Kidneys
/ Klebsiella pneumoniae - genetics
/ Lipids
/ Liver
/ Male
/ Mice
/ Non-alcoholic Fatty Liver Disease - metabolism
/ Phages
/ Safety
/ Science
/ Therapy
