Journal Article

Functionalized MoS2-nanosheets with NIR-Triggered nitric oxide delivery and photothermal activities for synergistic antibacterial and regeneration-promoting therapy

Hu, Rongdang, Jin, Ting, Chen, Yuanqi, Huang, Chen, Mu, Zhixiang, Lei, Kezheng, Chu, Tengda, Li, Sisi, Zeng, BaiRui, Deng, Hui, Lu, Hongyang, Cai, Xiaojun

2023

Overview

Bacterial infection in skin and soft tissue has emerged as a critical concern. Overreliance on antibiotic therapy has led to numerous challenges, including the emergence of multidrug-resistant bacteria and adverse drug reactions. It is imperative to develop non-antibiotic treatment strategies that not only exhibit potent antibacterial properties but also promote rapid wound healing and demonstrate biocompatibility. Herein, a novel multimodal synergistic antibacterial system (SNO-CS@MoS 2 ) was developed. This system employs easily surface-modified thin-layer MoS 2 as photothermal agents and loaded with S-nitrosothiol-modified chitosan (SNO-CS) via electrostatic interactions, thus realizing the combination of NO gas therapy and photothermal therapy (PTT). Furthermore, this surface modification renders SNO-CS@MoS 2 highly stable and capable of binding with bacteria. Through PTT’s thermal energy, SNO-CS@MoS 2 rapidly generates massive NO, collaborating with PTT to achieve antibacterial effects. This synergistic therapy can swiftly disrupt the bacterial membrane, causing protein leakage and ATP synthesis function damage, ultimately eliminating bacteria. Notably, after effectively eliminating all bacteria, the residual SNO-CS@MoS 2 can create trace NO to promote fibroblast migration, proliferation, and vascular regeneration, thereby accelerating wound healing. This study concluded that SNO-CS@MoS 2 , a novel multifunctional nanomaterial with outstanding antibacterial characteristics and potential to promote wound healing, has promising applications in infected soft tissue wound treatment.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acids / Advanced 2D nanomaterials for biomedical applications / Angiogenesis / Antibacterial / Antibacterial activity / Antibacterial agents / Antibiotics / Bacteria / Bacterial diseases / Bacterial infections / Bacterial skin diseases / Biocompatibility / Biotechnology / Care and treatment / Cell growth / Chemical properties / Chemistry / Chemistry and Materials Science / Chitosan / Drug resistance / Drug resistance in microorganisms / Electrostatic properties / Enzymes / Fibroblasts / Health aspects / Heat resistance / Infection / Kinases / Materials research / Membrane proteins / Methods / Microscopy / Molecular Medicine / Molybdenum disulfide / Multidrug resistance / Nanomaterials / Nanoparticles / Nanosheets / Nanotechnology / Nitric oxide / NO gas therapy / Phototherapy / Photothermal therapy / Physiology / Promoting wound healing / Protein biosynthesis / Proteins / Regeneration / Regeneration (Biology) / Side effects / Skin / Soft tissues / Temperature / Therapy / Thermal energy / Wound healing / Wounds and injuries