Journal Article

Improved outcomes in patients with positive metal sensitivity following revision total knee arthroplasty

Brazier, Brett G., Zondervan, Robert L., Taunt, Charles J., Vaux, Jonathan J., Blackmer, Michael J.

2019

Overview

Background Metal sensitivity as a cause for painful joint replacement has become increasingly prevalent; however, there is a lack of reported clinical outcome data from total knee arthroplasty patients with metal allergies. The purpose of this study was to determine whether patients presenting with a painful total knee arthroplasty with a positive metal sensitivity have improved outcomes following revision to a hypoallergenic implant. Methods A retrospective review was conducted for patients that underwent a revision total knee arthroplasty after metal sensitivity testing over a 3-year period from January 1, 2015, to December 31, 2017. Based on the results of sensitivity testing, patients underwent revision total knee arthroplasty to a hypoallergenic component or a standard component. Following revision, patients returned to the clinic at an interval of 6 weeks, 5 months, and 12 months for functional, pain, and satisfaction assessment. Outcomes were compared within and between sensitivity groups. Results Of the included patients, 78.3% (39/46) were positive for metal sensitivity. The most common metal sensitivity was to nickel (79.5%, 32/39). Both non-reactive and reactive patients significantly improved in range of motion after revision arthroplasty. The reactive group saw a 37.8% decrease in pain at 6 weeks post-revision ( p  < 0.001) Whereas, the non-reactive group only saw a moderate, non-significant improvement in pain reduction at 6 weeks post-revision (27.0%; p  = 0.29). Frequency of pain experienced did not vary significantly between groups. Maximum metal lymphocyte transformation test (LTT) sensitivity score did not correlate with pain level at the time of revision ( R 2  = 0.02, p  = 0.38) or percent improvement after revision ( R 2  = 0.001, p  = 0.81). Overall, all patients reported being very satisfied after revision total knee arthroplasty; there was no difference between positive and negative sensitivity groups ( W  = 62, p  = 0.89). Conclusions Patients presenting with a painful knee arthroplasty and positive metal LTT have improved pain scores, walking function, and range of motion following revision to a hypoallergenic component. This study also provides a treatment algorithm for patients presenting with a painful knee replacement, in order to provide effective and timely diagnosis and management.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Algorithms / Allergies / Allergy / Allergy tests / Antigens / Arthroplasty / Arthroplasty (knee) / Arthroplasty, Replacement, Knee - adverse effects / Arthroplasty, Replacement, Knee - statistics & numerical data / Care and treatment / Causes of / Complications and side effects / Equipment and supplies / Female / Hip / Humans / Hypersensitivity - complications / Infections / Joint replacement / Joint surgery / Knee / Knee Prosthesis - adverse effects / Knee replacement arthroplasty / Laboratories / Lymphocyte transformation / Lymphocytes / Male / Medical research / Medicine / Medicine & Public Health / Metal allergy / Metal sensitivity / Metals / Metals (Materials) / Metals - adverse effects / Methods / Middle Aged / Nickel / Orthopedic implants / Orthopedic surgery / Orthopedics / Out of pocket costs / Pain / Pain management / Patient outcomes / Patients / Postoperative complications / Preoperative care / Reoperation / Reoperation - statistics & numerical data / Research Article / Retrospective Studies / Surgical Orthopedics / Transplants & implants / Treatment Outcome / Walking