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Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
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Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
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Journal Article
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
2025
Overview
Background
This study aimed to explore associations between the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and the risk of incident cardiovascular disease (CVD) and arrhythmias, together with comparing to three other pre-existing diet quality indices.
Methods
A prospective analysis was conducted using the UK Biobank. MIND diet score, Mediterranean Diet Adherence Screener (MEDAS), Recommended Food Score (RFS), and Healthy Diet Indicator (HDI) were computed using the Oxford WebQ. Cox proportional hazards regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI).
Results
193,983 participants were included in the CVD analyses, and 190,529 for arrhythmias. Compared with participants in the lowest quartile of MIND diet score, participants in the highest quartile had a lower risk of CVD (HR 0.86; 95% CI 0.81–0.91), ischemic heart disease (0.92; 0.85–0.98), stroke (0.86; 0.75–0.97), heart failure (0.79; 0.71–0.88), and total arrhythmias (0.93; 0.88–0.99), after adjusting for demographics, lifestyle, and chronic conditions. With further adjustment for metabolic profiles, the associations remain significant for CVD and its subtypes but become non-significant for arrhythmias. Strengths of association varied across diet scores, with associations for MEDAS (CVD and arrhythmias) and MIND (CVD subtypes). The associations with CVD were linear for MIND and MEDAS and non-linear for RFS. The association between MEDAS and arrhythmias was non-linear. We observed significant interactions by age and obesity for CVD.
Conclusions
The MIND diet was associated with CVD and arrhythmias, relying on a single day of dietary data to derive dietary patterns. The findings suggest that following the MIND diet was associated with a lower risk of CVD, heart failure specifically, and arrhythmias.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Arrhythmias, Cardiac - epidemiology
/ Arrhythmias, Cardiac - prevention & control
/ Biobanks
/ Cardiomyopathy and cardiac arrhythmias
/ Cardiovascular Diseases - epidemiology
/ Cardiovascular Diseases - prevention & control
/ Cohort
/ CVD
/ Diet
/ Dietary Approaches To Stop Hypertension - methods
/ Female
/ Food
/ Fruits
/ Humans
/ Interactive computer systems
/ Ischemia
/ Legumes
/ Male
/ Meat
/ Medicine
/ Nuts
/ Risk
/ Sugar
