Journal Article

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

Department of Medicine ; University of California [San Diego] (UC San Diego) ; University of California (UC)-University of California (UC), Humphrey, G, Singh, S, Inter-University Accelerator Center (IUC) ; University Grants Commission (UGC), Loomba, R, Brenner, D. A, Evans, R. M, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) ; Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sirlin, C. B, Caussy, C, Richards, L, Rizo, E, Bettencourt, R, Hôpital Louis Pradel [CHU - HCL] ; Hospices Civils de Lyon (HCL), Downes, M. R, University of California [San Diego] (UC San Diego) ; University of California (UC), UC San Diego NAFLD Research Center ; Schoo

2019

Overview

The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiome-derived signature to detect NAFLD-cirrhosis.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 45/22 / 45/23 / 59/57 / 692/4020/4021/1607/1604 / 692/4020/4021/1607/2750 / 692/53/2422 / Accuracy / Bacteria - classification / Cirrhosis / Diagnostic systems / Digestive system / Disease control / Family / Fatty liver / Fecal microflora / Feces - microbiology / Female / Gastrointestinal Microbiome / Gut microbiota / Health risk assessment / Humanities and Social Sciences / Humans / Intestinal microflora / Life Sciences / Liver / Liver cirrhosis / Liver Cirrhosis - microbiology / Liver diseases / Magnetic resonance / Male / Microbiomes / Microbiota / Model accuracy / Mortality / multidisciplinary / Non-alcoholic Fatty Liver Disease - microbiology / Phylogenetics / ROC Curve / Science / Science (multidisciplinary)