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Activation of adult-born neurons facilitates learning and memory
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Journal Article
Activation of adult-born neurons facilitates learning and memory
2012
Overview
Using optogenetic activation of adult-born neurons in the mouse olfactory bulb, the authors find that selective stimulation of new interneurons generated during adulthood, but not earlier, accelerates learning in a two-odor discrimination task and improves olfactory memory.
Thousand of local interneurons reach the olfactory bulb of adult rodents every day, but the functional effect of this process remains elusive. By selectively expressing channelrhodopsin in postnatal-born mouse neurons, we found that their activation accelerated difficult odor discrimination learning and improved memory. This amelioration was seen when photoactivation occurred simultaneously with odor presentation, but not when odor delivery lagged by 500 ms. In addition, learning was facilitated when light flashes were delivered at 40 Hz, but not at 10 Hz. Both
in vitro
and
in vivo
electrophysiological recordings of mitral cells revealed that 40-Hz stimuli produced enhanced GABAergic inhibition compared with 10-Hz stimulation. Facilitation of learning occurred specifically when photoactivated neurons were generated during adulthood. Taken together, our results demonstrate an immediate causal relationship between the activity of adult-born neurons and the function of the olfactory bulb circuit.
Publisher
Nature Publishing Group US,Nature Publishing Group
