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Female sexual behavior in mice is controlled by kisspeptin neurons
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Female sexual behavior in mice is controlled by kisspeptin neurons
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Journal Article
Female sexual behavior in mice is controlled by kisspeptin neurons
2018
Overview
Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that male odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.
Mate preference and copulatory behavior in female rodents are coordinated with the ovulation cycles of the animal. This study shows that hypothalamic kisspeptin neurons control both mate choice and copulation, and therefore, that sexual behavior and ovulation may be synchronized by the same neuropeptide.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 14/34
/ 14/63
/ 38/44
/ 38/77
/ 64/110
/ 64/60
/ Animals
/ Brain
/ Female
/ Females
/ Gonadotropin-Releasing Hormone - metabolism
/ Gonadotropin-Releasing Hormone/secretion
/ Humanities and Social Sciences
/ Kisspeptins/genetics/metabolism
/ Male
/ Mice
/ Neurons
/ Neurosciences & comportement
/ Nitric Oxide Synthase - metabolism
/ Odorants
/ Odors
/ Posture
/ Rodents
/ Science
/ Sciences sociales & comportementales, psychologie
/ Sexual Behavior, Animal - physiology
/ Social & behavioral sciences, psychology
