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The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

by Westermayer, Sandra , Fischer, Katrin , Sexl, Veronika , Szappanos, Daniel , Bennett, Keiryn L. , Kallinger, Fabian , Novatchkova, Maria , Platanitis, Ekaterini , Lassnig, Caroline , Müller, Mathias , Decker, Thomas , Penninger, Josef M. , Tschismarov, Roland , Perlot, Thomas , Foong-Sobis, Michelle

in Animals / Antimicrobial agents / Biology and Life Sciences / Biotechnology / Bone composition / Bone marrow / Breeding of animals / Cell cycle / Chemokines / Cytokines / DEAD-box RNA Helicases - metabolism / Disease Resistance - immunology / DNA helicase / Female / Fibroblasts - immunology / Fibroblasts - pathology / Genes / Genomes / HEK293 Cells / Hematopoiesis / Hematopoiesis - immunology / Humans / Immune response / Immune system / Immunity / Immunity, Innate / Immunology / Infection / Infections / Inflammatory diseases / Innate immunity / Isoforms / Killer Cells, Natural - immunology / Kinases / Laboratories / Leukocytes / Listeria / Listeria monocytogenes / Listeria monocytogenes - immunology / Listeriosis - immunology / Listeriosis - pathology / Lymphocytes - immunology / Male / Medicine and Health Sciences / Mice / Mice, Knockout / Microorganisms / NF-kappa B - immunology / Perutz, Max / Receptors / Research and Analysis Methods / RNA / RNA helicase / RNA Helicases - deficiency / RNA Helicases - genetics / RNA Helicases - immunology / Sex / Sex differences / Sex Factors / Signal Transduction / Spleen / Tumorigenesis / Veterinary medicine / Viral infections / Viruses

2018

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The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

2018

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The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

2018

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Journal Article

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

Westermayer, Sandra,

Fischer, Katrin,

Sexl, Veronika,

Szappanos, Daniel,

Bennett, Keiryn L.,

Kallinger, Fabian,

Novatchkova, Maria,

Platanitis, Ekaterini,

Lassnig, Caroline,

Müller, Mathias,

Decker, Thomas,

Penninger, Josef M.,

Tschismarov, Roland,

Perlot, Thomas,

Foong-Sobis, Michelle

2018

Overview

DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leukocyte composition in bone marrow and spleen and a striking inability to combat infection with Listeria monocytogenes. Alterations in innate immune responses resulted from decreased effector cell availability and function as well as a sex-dependent impairment of cytokine synthesis. Thus, our data provide further in vivo evidence for an essential contribution of a non-RLR DExD/H RNA helicase to innate immunity and suggest it may contribute to sex-related differences in resistance to microbes and resilience to inflammatory disease.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Animals

/ Antimicrobial agents

/ Biology and Life Sciences

/ Biotechnology

/ Bone composition

/ Bone marrow

/ Breeding of animals