Journal Article

Programmatic implications of the TUMIKIA trial on community-wide treatment for soil-transmitted helminths: further health economic analyses needed before a change in policy

Bundy, Donald A. P., Turner, Hugo C.

2020

Overview

School-based deworming programmes are currently the main approach used to control the soil-transmitted helminths (STHs). A key unanswered policy question is whether mass drug administration (MDA) should be targeted to the whole community instead, and several trials in this area have been conducted or are currently on-going. A recent well-conducted trial demonstrated that successful community-wide treatment is a feasible strategy for STH control and can be more effective than school-based treatment in reducing prevalence and intensity of hookworm infection. However, we would argue that it is vital that these findings are not taken out of context or over generalised, as the additional health benefits gained from switching to community-wide treatment will vary depending on the STH species and baseline endemicity. Moreover, community-wide treatment will typically be more expensive than school-based treatment. The epidemiological evidence for an additional benefit from a switch to community-wide treatment has yet to be proven to represent “good value for money” across different settings. Further work is needed before changes in policy are made regarding the use of community-wide treatment for STH control, including comprehensive assessments of its additional public health benefits and costs across a range of scenarios, accounting for the presence of alternative treatment delivery platforms.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Animals / Anthelmintics - administration & dosage / Anthelmintics - economics / Biomedical and Life Sciences / Biomedicine / Chemotherapy / Child / Child, Preschool / Clinical trials / Community-wide treatment / Comparative analysis / Cost / Costs / Deworming / drugs / Economic analysis / Economics / Entomology / Epidemiology / Female / Health care costs / Health Policy - economics / Helminthiasis / Helminthiasis - drug therapy / Helminthiasis - economics / Helminthiasis - parasitology / Helminths - drug effects / Helminths - isolation & purification / Helminths - physiology / hookworms / Humans / indigenous species / Infection / Infections / Infectious Diseases / issues and policy / Kenya / Letter to the Editor / Male / Mathematical models / Medical economics / Morbidity / Parasites / Parasitology / Pediatric diseases / Policies / Policy / Prevention / Public health / Public health administration / Public health movements / Residence Characteristics / Retirement benefits / School-based treatment / Setting (Literature) / Soil / Soil - parasitology / Soil treatment / Soil-transmitted helminths / Studies / Tropical diseases / Tropical Medicine / Veterinary Medicine/Veterinary Science / Virology