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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
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Journal Article
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
2011
Overview
Johnson and colleagues investigate spiking activity in developing inner hair cells (IHCs), showing that apical IHCs fire spontaneous action potentials in a burst-like pattern, whereas basal IHCs fire randomly. The burst-like firing of apical IHCs depends on acetylcholine. Extracellular ATP affects the resting potential of IHCs by activating SK2 channels.
Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials were intrinsically generated by immature IHCs of altricial rodents and that apical IHCs showed bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter acetylcholine fine-tunes the IHC's resting membrane potential (
V
m
), and as such is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the
V
m
of apical and basal IHCs by triggering small-conductance Ca
2+
-activated K
+
(SK2) channels. We propose that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway.
Publisher
Nature Publishing Group US,Nature Publishing Group
