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Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo
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Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo
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Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo
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Journal Article
Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo
2019
Overview
Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal septate-like junctions of peripheral and central myelinated axons. The genetic deletion of Nfasc155 results in the loss of septate-like junctions and in conduction slowing. In humans, IgG4 antibodies against Nfasc155 are implicated in the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP). These antibodies are associated with an aggressive onset, a refractoriness to intravenous immunoglobulin, and tremor of possible cerebellar origin. Here, we examined the pathogenic effects of patient-derived anti-Nfasc155 IgG4. These antibodies did not inhibit the ability of Nfasc155 to complex with its axonal partners contactin-1/CASPR1 or induce target internalization. Passive transfer experiments revealed that IgG4 antibodies target Nfasc155 on Schwann cell surface, and diminished Nfasc155 protein levels and prevented paranodal complex formation in neonatal animals. In adult animals, chronic intrathecal infusions of antibodies also induced the loss of Nfasc155 and of paranodal specialization and resulted in conduction alterations in motor nerves. These results indicate that anti-Nfasc155 IgG4 perturb conduction in absence of demyelination, validating the existence of paranodopathy. These results also shed light on the mechanisms regulating protein insertion at paranodes.
Publisher
American Society for Clinical Investigation
Subject
/ Animals
/ Biopsy
/ Cell Adhesion Molecules - antagonists & inhibitors
/ Cell Adhesion Molecules - immunology
/ Female
/ Humans
/ Immunoglobulin G - immunology
/ Immunoglobulin G - pharmacology
/ Male
/ Neonates
/ Nerve Growth Factors - antagonists & inhibitors
/ Nerve Growth Factors - immunology
/ Nerves
/ Patients
/ Polyneuropathies - drug therapy
/ Polyneuropathies - immunology
/ Polyneuropathies - pathology
/ Polyradiculoneuropathy - drug therapy
/ Polyradiculoneuropathy - immunology
/ Polyradiculoneuropathy - pathology
/ Proteins
/ Rats
/ Tremor
