Journal Article

Socioeconomic Inequality in the Prevalence of Autism Spectrum Disorder: Evidence from a U.S. Cross-Sectional Study

DiGuiseppi, Carolyn, Durkin, Maureen S., Nicholas, Joyce S., Maenner, Matthew J., Kirby, Russell S., Schieve, Laura A., Levy, Susan E., Meaney, F. John, Pinto-Martin, Jennifer A.

2010

Overview

This study was designed to evaluate the hypothesis that the prevalence of autism spectrum disorder (ASD) among children in the United States is positively associated with socioeconomic status (SES). A cross-sectional study was implemented with data from the Autism and Developmental Disabilities Monitoring Network, a multiple source surveillance system that incorporates data from educational and health care sources to determine the number of 8-year-old children with ASD among defined populations. For the years 2002 and 2004, there were 3,680 children with ASD among a population of 557,689 8-year-old children. Area-level census SES indicators were used to compute ASD prevalence by SES tertiles of the population. Prevalence increased with increasing SES in a dose-response manner, with prevalence ratios relative to medium SES of 0.70 (95% confidence interval [CI] 0.64, 0.76) for low SES, and of 1.25 (95% CI 1.16, 1.35) for high SES, (P<0.001). Significant SES gradients were observed for children with and without a pre-existing ASD diagnosis, and in analyses stratified by gender, race/ethnicity, and surveillance data source. The SES gradient was significantly stronger in children with a pre-existing diagnosis than in those meeting criteria for ASD but with no previous record of an ASD diagnosis (p<0.001), and was not present in children with co-occurring ASD and intellectual disability. The stronger SES gradient in ASD prevalence in children with versus without a pre-existing ASD diagnosis points to potential ascertainment or diagnostic bias and to the possibility of SES disparity in access to services for children with autism. Further research is needed to confirm and understand the sources of this disparity so that policy implications can be drawn. Consideration should also be given to the possibility that there may be causal mechanisms or confounding factors associated with both high SES and vulnerability to ASD.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Autism / Bias / Birth weight / Census of Population / Child / Child Development Disorders, Pervasive - epidemiology / Children / Collaboration / Confidence intervals / Cross-Sectional Studies / Cultural differences / Developmental disabilities / Diagnosis / Diagnostic systems / Disabilities / Disease control / Economic indicators / Education / Enrollments / Epidemiology / Female / Health care / Health disparities / Health sciences / Health surveillance / Humans / Hypotheses / Inequality / Inflammatory diseases / Intellectual disabilities / Male / Medical research / Medicine / Mental disorders / Minority & ethnic groups / Pediatrics / Pediatrics and Child Health/Developmental and Pediatric Neurology / Public health / Public Health and Epidemiology/Epidemiology / Public Health and Epidemiology/Social and Behavioral Determinants of Health / Social aspects / Social Class / Socioeconomic factors / Socioeconomics / Studies / Surveillance / United States - epidemiology