Asset Details
Do you wish to reserve the book?
COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention
Do you wish to request the book?
COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention
2017
Overview
Attention capture by potentially relevant environmental stimuli is critical for human survival, yet it varies considerably among individuals. A large series of studies has suggested that attention capture may depend on the cognitive balance between maintenance and manipulation of mental representations and the flexible switch between goal-directed representations and potentially relevant stimuli outside the focus of attention; a balance that seems modulated by a prefrontostriatal dopamine pathway. Here, we examined inter-individual differences in the cognitive control of attention through studying the effects of two single nucleotide polymorphisms regulating dopamine at the prefrontal cortex and the striatum (i.e., COMTMet108/158Val and ANKK1/DRD2TaqIA) on stimulus-driven attention capture. Healthy adult participants (N = 40) were assigned to different groups according to the combination of the polymorphisms COMTMet108/158Val and ANKK1/DRD2TaqIA, and were instructed to perform on a well-established distraction protocol. Performance in individuals with a balance between prefrontal dopamine display and striatal receptor density was slowed down by the occurrence of unexpected distracting events, while those with a rather unbalanced dopamine activity were able maintain task performance with no time delay, yet at the expense of a slightly lower accuracy. This advantage, associated to their distinct genetic profiles, was paralleled by an electrophysiological mechanism of phase-resetting of gamma neural oscillation to the novel, distracting events. Taken together, the current results suggest that the epistatic interaction between COMTVal108/158Met and ANKK1/DRD2 TaqIa genetic polymorphisms lies at the basis of stimulus-driven attention capture.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Analysis
/ Atenció
/ Catechol O-Methyltransferase - genetics
/ Catechol O-Methyltransferase - physiology
/ Cognició
/ Corpus Striatum - physiology
/ Dopamina
/ Dopamine
/ Enzymes
/ Female
/ Humans
/ Kinases
/ Male
/ Medicine and Health Sciences
/ Memory
/ Memory, Short-Term - physiology
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - physiology
/ Neurons
/ Polymorphism, Single Nucleotide
/ Prefrontal Cortex - physiology
/ Protein-Serine-Threonine Kinases - genetics
/ Protein-Serine-Threonine Kinases - physiology
/ Receptors, Dopamine D2 - genetics
/ Receptors, Dopamine D2 - physiology
/ Research and Analysis Methods
/ Single-nucleotide polymorphism
/ Stimuli
/ Time lag
/ Trends
