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Morphing electronics enable neuromodulation in growing tissue
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Journal Article
Morphing electronics enable neuromodulation in growing tissue
2020
Overview
Bioelectronics for modulating the nervous system have shown promise in treating neurological diseases
1
–
3
. However, their fixed dimensions cannot accommodate rapid tissue growth
4
,
5
and may impair development
6
. For infants, children and adolescents, once implanted devices are outgrown, additional surgeries are often needed for device replacement, leading to repeated interventions and complications
6
–
8
. Here, we address this limitation with morphing electronics, which adapt to in vivo nerve tissue growth with minimal mechanical constraint. We design and fabricate multilayered morphing electronics, consisting of viscoplastic electrodes and a strain sensor that eliminate the stress at the interface between the electronics and growing tissue. The ability of morphing electronics to self-heal during implantation surgery allows a reconfigurable and seamless neural interface. During the fastest growth period in rats, morphing electronics caused minimal damage to the rat nerve, which grows 2.4-fold in diameter, and allowed chronic electrical stimulation and monitoring for 2 months without disruption of functional behavior. Morphing electronics offers a path toward growth-adaptive pediatric electronic medicine.
Viscoplastic electronic devices adapt as nerves enlarge in growing animals.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biocompatible Materials - chemistry
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Children
/ Electronics, Medical - instrumentation
/ Electronics, Medical - methods
/ Growth
/ Implantable Neurostimulators
/ Implants
/ Infants
/ Letter
/ Methods
/ Morphing
/ Nerves
/ Rats
/ Sensors
/ Surgery
/ Tissues
