Journal Article

Predictors of lower limb fractures in general Japanese: NIPPON DATA90

Akira Okayama, Tomonori Okamura, Keiko Kondo, Sayuki Torii, Akira Fujiyoshi, Hisatomi Arima, Hirotsugu Ueshima, Yoshikuni Kita, Toshiyuki Iwahori, Naoko Miyagawa, Yoshino Saito, Naoyuki Takashima, Katsuyuki Miura, Takehito Hayakawa, Takayoshi Ohkubo, NIPPON DATA90 Research Group, Aya Kadota, Nagako Okuda

2022

Overview

This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population. NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures). The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age. Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.

• Publisher: Public Library of Science (PLoS),Public Library of Science
• Subject: Activities of daily living / Age / Age Factors / Aged / Aging / Alcohol / Biology and Life Sciences / Body mass / Body Mass Index / Body size / Calcium, Dietary / Databases, Factual / Dosage and administration / Epidemiology / Exercise / Female / Femoral Fractures / Femoral Fractures - epidemiology / Femur / Food / Fractures / Fractures, Bone / Fractures, Bone - epidemiology / Health aspects / Health care / Households / Humans / Incidence / Injuries / Japan / Leg / Lower Extremity / Male / Medicine / Medicine and Health Sciences / Middle Aged / Nutrients / Nutrition / Nutrition Surveys / Participation / People and Places / Physical fitness / Physiological aspects / Polls & surveys / Preventive medicine / Proportional Hazards Models / Prospective Studies / Public health / Q / Questionnaires / R / Research Article / Risk analysis / Risk assessment / Risk Factors / Science / Vegetables / Womens health