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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
by
Lashner, Bret
, McChalicher, Christopher W.J
, Winkler, Jonathan A
, Wortman, Jennifer R
, Korman, Louis Y
, Louie, Thomas J
, Lombardo, Mary-Jane
, Berenson, Charles S
, Sims, Matthew
, Diao, Liyang
, Henn, Matthew R
, Cohen, Stuart H
, McGovern, Barbara H
, Auniņš, John G
, Wang, Elaine E.L
, Kraft, Colleen S
, Wu, Henry
, Trucksis, Michele
, Feuerstadt, Paul
, von Moltke, Lisa
, Bryant, Jessica A
, Ford, Christopher B
, Litcofsky, Kevin D
in
Acids
/ Age
/ Aged
/ Anti-Bacterial Agents - adverse effects
/ Antibiotics
/ Bacillota
/ Bacteria
/ Bacterial Infections
/ Bile
/ Clostridioides difficile
/ Clostridium Infections - therapy
/ Coronaviruses
/ COVID-19
/ Cytotoxicity
/ Double-Blind Method
/ Drug dosages
/ Enzymes
/ Feces
/ Feces - microbiology
/ Female
/ Gastroenterology
/ Gastroenterology General
/ Gastrointestinal Tract - microbiology
/ Humans
/ Hypotheses
/ Immunoassay
/ Infections
/ Infectious Disease
/ Infectious Disease General
/ Intention to Treat Analysis
/ Laboratories
/ Male
/ Manufacturing
/ Microbiomes
/ Microbiota
/ Microbiota - drug effects
/ Middle Aged
/ Oral administration
/ Patients
/ Placebos
/ Recurrence
/ Recurrent infection
/ Secondary Prevention
/ Spore germination
/ Spores, Bacterial
/ Statistical analysis
/ Vancomycin
2022
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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
by
Lashner, Bret
, McChalicher, Christopher W.J
, Winkler, Jonathan A
, Wortman, Jennifer R
, Korman, Louis Y
, Louie, Thomas J
, Lombardo, Mary-Jane
, Berenson, Charles S
, Sims, Matthew
, Diao, Liyang
, Henn, Matthew R
, Cohen, Stuart H
, McGovern, Barbara H
, Auniņš, John G
, Wang, Elaine E.L
, Kraft, Colleen S
, Wu, Henry
, Trucksis, Michele
, Feuerstadt, Paul
, von Moltke, Lisa
, Bryant, Jessica A
, Ford, Christopher B
, Litcofsky, Kevin D
in
Acids
/ Age
/ Aged
/ Anti-Bacterial Agents - adverse effects
/ Antibiotics
/ Bacillota
/ Bacteria
/ Bacterial Infections
/ Bile
/ Clostridioides difficile
/ Clostridium Infections - therapy
/ Coronaviruses
/ COVID-19
/ Cytotoxicity
/ Double-Blind Method
/ Drug dosages
/ Enzymes
/ Feces
/ Feces - microbiology
/ Female
/ Gastroenterology
/ Gastroenterology General
/ Gastrointestinal Tract - microbiology
/ Humans
/ Hypotheses
/ Immunoassay
/ Infections
/ Infectious Disease
/ Infectious Disease General
/ Intention to Treat Analysis
/ Laboratories
/ Male
/ Manufacturing
/ Microbiomes
/ Microbiota
/ Microbiota - drug effects
/ Middle Aged
/ Oral administration
/ Patients
/ Placebos
/ Recurrence
/ Recurrent infection
/ Secondary Prevention
/ Spore germination
/ Spores, Bacterial
/ Statistical analysis
/ Vancomycin
2022
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Do you wish to request the book?
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
by
Lashner, Bret
, McChalicher, Christopher W.J
, Winkler, Jonathan A
, Wortman, Jennifer R
, Korman, Louis Y
, Louie, Thomas J
, Lombardo, Mary-Jane
, Berenson, Charles S
, Sims, Matthew
, Diao, Liyang
, Henn, Matthew R
, Cohen, Stuart H
, McGovern, Barbara H
, Auniņš, John G
, Wang, Elaine E.L
, Kraft, Colleen S
, Wu, Henry
, Trucksis, Michele
, Feuerstadt, Paul
, von Moltke, Lisa
, Bryant, Jessica A
, Ford, Christopher B
, Litcofsky, Kevin D
in
Acids
/ Age
/ Aged
/ Anti-Bacterial Agents - adverse effects
/ Antibiotics
/ Bacillota
/ Bacteria
/ Bacterial Infections
/ Bile
/ Clostridioides difficile
/ Clostridium Infections - therapy
/ Coronaviruses
/ COVID-19
/ Cytotoxicity
/ Double-Blind Method
/ Drug dosages
/ Enzymes
/ Feces
/ Feces - microbiology
/ Female
/ Gastroenterology
/ Gastroenterology General
/ Gastrointestinal Tract - microbiology
/ Humans
/ Hypotheses
/ Immunoassay
/ Infections
/ Infectious Disease
/ Infectious Disease General
/ Intention to Treat Analysis
/ Laboratories
/ Male
/ Manufacturing
/ Microbiomes
/ Microbiota
/ Microbiota - drug effects
/ Middle Aged
/ Oral administration
/ Patients
/ Placebos
/ Recurrence
/ Recurrent infection
/ Secondary Prevention
/ Spore germination
/ Spores, Bacterial
/ Statistical analysis
/ Vancomycin
2022
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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
Journal Article
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
2022
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Overview
A major challenge with the treatment of
Clostridioides difficile
infection is restoring the antibiotic-associated alterations of bowel flora to a state less hospitable to
C. difficile
. In this trial, a microbiome-replacement therapy, SER-109, was used to treat patients with recurrent
C. difficile
infection and was shown to reduce the risk of further recurrence.
Publisher
Massachusetts Medical Society
Subject
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