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Tumour cell invasiveness and response to chemotherapeutics in adipocyte invested 3D engineered anisotropic collagen scaffolds

by Hitchcock, Jessica , Watson, Christine J. , Pensa, Sara , Brown, Elizabeth J. , Kreuzaler, Peter A. , Husmann, Anke , Cameron, Ruth E. , Hume, Robert D. , Campbell, Jonathan J. , Lloyd-Thomas, Annabel O.

in 13 / 13/107 / 14 / 14/19 / 14/28 / 14/69 / 3T3-L1 Cells / 631/61/2035 / 631/67/1347 / 631/67/70 / Adipocytes / Adipocytes - cytology / Animals / Anisotropy / Breast cancer / Cell adhesion & migration / Cell culture / Cell migration / Cell Movement - physiology / Collagen / Collagen - chemistry / Drugs / Female / Humanities and Social Sciences / Humans / Immunofluorescence / Immunohistochemistry / Invasiveness / Kinases / Metastases / Metastasis / Mice / Mice, Inbred BALB C / Microscopy / Microscopy, Confocal / Microscopy, Fluorescence / multidisciplinary / Proteins / Science / Science (multidisciplinary) / Stroma / Tennis / Tissue Engineering - methods / Tissue Scaffolds - chemistry / Tumors

2018

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Tumour cell invasiveness and response to chemotherapeutics in adipocyte invested 3D engineered anisotropic collagen scaffolds

2018

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2018

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Journal Article

Tumour cell invasiveness and response to chemotherapeutics in adipocyte invested 3D engineered anisotropic collagen scaffolds

Hitchcock, Jessica,

Watson, Christine J.,

Pensa, Sara,

Brown, Elizabeth J.,

Kreuzaler, Peter A.,

Husmann, Anke,

Cameron, Ruth E.,

Hume, Robert D.,

Campbell, Jonathan J.,

Lloyd-Thomas, Annabel O.

2018

Overview

Breast cancers are highly heterogeneous and their metastatic potential and response to therapeutic drugs is difficult to predict. A tool that could accurately gauge tumour invasiveness and drug response would provide a valuable addition to the oncologist’s arsenal. We have developed a 3-dimensional (3D) culture model that recapitulates the stromal environment of breast cancers by generating anisotropic (directional) collagen scaffolds seeded with adipocytes and culturing tumour fragments therein. Analysis of tumour cell invasion in the presence of various therapeutic drugs, by immunofluorescence microscopy coupled with an optical clearing technique, demonstrated the utility of this approach in determining both the rate and capacity of tumour cells to migrate through the stroma while shedding light also on the mode of migration. Furthermore, the response of different murine mammary tumour types to chemotherapeutic drugs could be readily quantified.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 13/107

/ 14

/ 14/19

/ 14/28

/ 14/69

/ 3T3-L1 Cells

/ 631/61/2035