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Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer
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Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer
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Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer
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Journal Article
Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer
2024
Overview
Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with non-small cell lung cancer (NSCLC). We identify a dose–response relationship between aneuploidy score and patient outcomes. In two independent NSCLC cohorts (n = 659 patients), we demonstrate a novel association between elevated aneuploidy and non-smoking-associated oncogenic driver mutations. Lastly, we report enrichment of
TERT
amplification and immune-suppressive phenotypes of highly aneuploid NSCLC. Taken together, our findings emphasize a potentially critical role for tumor aneuploidy in guiding immunotherapy treatment strategies.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Aged
/ Biomarkers, Tumor - genetics
/ Carcinoma, Non-Small-Cell Lung - genetics
/ Carcinoma, Non-Small-Cell Lung - mortality
/ Carcinoma, Non-Small-Cell Lung - pathology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mutation
/ Non-small cell lung carcinoma
/ Patients
/ Science
/ Tumors
