Asset Details
Do you wish to reserve the book?
NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
Do you wish to request the book?
NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
2018
Overview
Spinal cord injury (SCI) often leads to permanent loss of motor, sensory, and autonomic functions.We have previously shown that neurotrophin3 (NT3)-loaded chitosan biodegradable material allowed for prolonged slow release of NT3 for 14 weeks under physiological conditions. Here we report that NT3-loaded chitosan, when inserted into a 1-cm gap of hemisectioned and excised adult rhesus monkey thoracic spinal cord, elicited robust axonal regeneration. Labeling of cortical motor neurons indicated motor axons in the corticospinal tract not only entered the injury site within the biomaterial but also grew across the 1-cm-long lesion area and into the distal spinal cord. Through a combination of magnetic resonance diffusion tensor imaging, functional MRI, electrophysiology, and kinematics-based quantitative walking behavioral analyses, we demonstrated that NT3-chitosan enabled robust neural regeneration accompanied by motor and sensory functional recovery. Given that monkeys and humans share similar genetics and physiology, our method is likely translatable to human SCI repair.
Publisher
National Academy of Sciences
Subject
/ Axons
/ Chitosan
/ Diffusion Tensor Imaging - methods
/ Female
/ Functional magnetic resonance imaging
/ Genetics
/ Injuries
/ Monkeys
/ Motor Neurons - drug effects
/ Motors
/ Nerve Regeneration - drug effects
/ Neurotrophin 3 - pharmacology
/ NMR
/ Pyramidal Tracts - drug effects
/ Recovery
/ Recovery of Function - drug effects
/ Spinal Cord Injuries - drug therapy
/ Thorax
/ Walking
