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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
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Journal Article
Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
1997
Overview
Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atherosclerotic lesions. To examine the physiologic role of apoE secretion by the macrophage in atherogenesis, bone marrow transplantation was used to reconstitute C57BL/6 mice with macrophages that were either null or wild type for the apoE gene. After 13 weeks on an atherogenic diet, C57BL/6 mice reconstituted with apoE null marrow developed 10-fold more atherosclerosis than controls in the absence of significant differences in serum cholesterol levels or lipoprotein profiles. ApoE expression was absent in the macrophage-derived foam cells of C57BL/6 mice reconstituted with apoE null marrow. Thus, lack of apoE expression by the macrophage promotes foam cell formation. These data support a protective role for apoE expression by the macrophage in early atherogenesis.
Publisher
National Academy of Sciences of the United States of America,The National Academy of Sciences of the USA,National Academy of Sciences
Subject
/ Aorta
/ Apolipoproteins E - biosynthesis
/ Apolipoproteins E - deficiency
/ Apolipoproteins E - genetics
/ ARTERE
/ ARTERIAS
/ Arteriosclerosis - metabolism
/ blood
/ etiology
/ Female
/ GENE
/ GENES
/ genetics
/ LESION
/ LESIONES
/ Lesions
/ Macrophages - transplantation
/ Mice
/ MUTACION
/ MUTATION
/ Proteins
/ RATON
/ Rodents
/ SOURIS
