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Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa
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Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa
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Journal Article
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa
2018
Overview
Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle decisions such as sporulation and virulence. Here, we study interactions between two SKs from
Pseudomonas aeruginosa
, GacS and RetS, which control the switch between acute and chronic virulence. We demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation. These mechanisms play important roles in vivo and during infection, and exemplify an unprecedented degree of signal processing by SKs that may be exploited in other multikinase networks.
Bacteria respond to stresses using two-component systems consisting of sensor kinases (SKs) and response regulators. Here, Francis
et al
. reveal three specific interaction mechanisms between a pair of SKs that are important for regulation of virulence in the pathogen
Pseudomonas aeruginosa
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/1
/ 38/111
/ 38/88
/ 42/70
/ 45
/ 45/29
/ 45/77
/ 49
/ 64
/ 64/60
/ 82/80
/ 82/83
/ 96
/ Animals
/ Anti-Bacterial Agents - therapeutic use
/ Bacterial Proteins - metabolism
/ Biofilms
/ Female
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Mice
/ Moths
/ Phosphorylation - physiology
/ Phosphotransferases - metabolism
/ Protein Domains - physiology
/ Protein Interaction Maps - physiology
/ Proteins
/ Pseudomonas aeruginosa - pathogenicity
/ Pseudomonas aeruginosa - physiology
/ Pseudomonas Infections - drug therapy
/ Pseudomonas Infections - microbiology
/ Pseudomonas Infections - mortality
/ Science
/ Sensors
