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Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
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Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
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Journal Article
Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
2020
Overview
Norepinephrine adjusts sensory processing in cortical networks and gates plasticity enabling adaptive behavior. The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the consequences of these changes on distinct targets such as astrocytes, which exhibit norepinephrine-dependent Ca
2+
elevations during vigilance, are not well understood. Using in vivo two-photon imaging, we show that locomotion-induced Ca
2+
elevations in mouse astroglia are profoundly inhibited by ethanol, an effect that can be reversed by enhancing norepinephrine release. Vigilance-dependent astroglial activation is abolished by deletion of α
1A
-adrenergic receptor from astroglia, indicating that norepinephrine acts directly on these ubiquitous glial cells. Ethanol reduces vigilance-dependent Ca
2+
transients in noradrenergic terminals, but has little effect on astroglial responsiveness to norepinephrine, suggesting that ethanol suppresses their activation by inhibiting norepinephrine release. Since abolition of astroglia Ca
2+
activation does not affect motor coordination, global suppression of astroglial networks may contribute to the cognitive effects of alcohol intoxication.
The effects of norepinephrine on sensory processing in cortical networks are altered by recreational drugs like ethanol. The authors show that ethanol suppresses the activation of astrocytes by inhibiting norepinephrine release which may contribute to the cognitive effects of alcohol intoxication.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/35
/ 14/69
/ 64/110
/ Adrenergic alpha-Agonists - pharmacology
/ Alcoholic Intoxication - genetics
/ Alcoholic Intoxication - metabolism
/ Alcoholic Intoxication - physiopathology
/ Animals
/ Calcium
/ Drugs
/ Ethanol
/ Excitatory Amino Acid Transporter 1 - deficiency
/ Excitatory Amino Acid Transporter 1 - genetics
/ Female
/ Humanities and Social Sciences
/ Male
/ Mice
/ Microscopy, Fluorescence, Multiphoton
/ Networks
/ Norepinephrine - antagonists & inhibitors
/ Norepinephrine - pharmacology
/ Receptors, Adrenergic, alpha-1 - deficiency
/ Receptors, Adrenergic, alpha-1 - genetics
/ Science
