Journal Article

Clinical utility of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing severe neutropenia in metastatic colorectal cancer patients treated with FOLFOXIRI plus bevacizumab: a single-center retrospective study

Kitagawa, Yusuke, Ooki, Akira, Ota, Yumiko, Chin, Keisho, Suenaga, Mitsukuni, Osumi, Hiroki, Ogura, Mariko, Yamaguchi, Kensei, Takahari, Daisuke, Suzuki, Takeshi, Nakayama, Izuma, Shinozaki, Eiji, Wakatsuki, Takeru

2020

Overview

Background This study aimed to evaluate the efficacy and the safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) patients that received fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) plus bevacizumab (Bev) in clinical practice. Methods We retrospectively analyzed mCRC patients who received FOLFOXIRI plus Bev between December 2015 and December 2017. We evaluated the efficacy of PEG-G-CSF as preventing or treating grade 3 or 4 neutropenia, the overall response rate (ORR) according to the Response Evaluation Criteria in Solid Tumors version 1.1, progression-free survival (PFS), overall survival (OS), and adverse events of FOLFOXIRI plus Bev based on the Common Terminology Criteria for Adverse Events version 4.0. Results A total of 26 patients (median age 53.5 years) were included. The ORR rate was 65.3%, the median PFS was 9.6 months (7.2–16.9), and the median OS was 24.2 months (13.6–NA). Grade 3 or 4 neutropenia occurred in 53.8% of the patients, and febrile neutropenia occurred in 7.7%. PEG-G-CSF was given to 77.0% of the patients, including prophylactically ( n  = 9) and after the development of grade 3 or 4 neutropenia ( n  = 11). No patients experienced grade 3 or 4 neutropenia after the administration of PEG-G-CSF. In seven of the nine patients who received PEG-G-CSF prophylactically (77.8%), no dose adjustment was required. Conclusions PEG-G-CSF is useful in preventing severe neutropenia in mCRC patients treated with FOLFOXIRI plus Bev.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: 5-Fluorouracil / Adult / Aged / Antigens / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Bevacizumab / Bevacizumab - administration & dosage / Biomedical and Life Sciences / Biomedicine / Cancer metastasis / Cancer patients / Cancer Research / Cancer therapies / Care and treatment / Chemotherapy / Clinical outcomes / Colonies / Colony-stimulating factor / Colorectal cancer / Colorectal Neoplasms - drug therapy / Colorectal Neoplasms - pathology / Complications and side effects / Development and progression / Female / Fluorouracil - administration & dosage / FOLFOXIRI plus bevacizumab / Folinic acid / Follow-Up Studies / Granulocyte colony-stimulating factor / Granulocyte Colony-Stimulating Factor - administration & dosage / Granulocytes / Growth factors / Health Promotion and Disease Prevention / Hematology / Humans / Immunotherapy / Irinotecan / Irinotecan - administration & dosage / Leucovorin - administration & dosage / Leukocytes (granulocytic) / Liver Neoplasms - drug therapy / Liver Neoplasms - secondary / Lung Neoplasms - drug therapy / Lung Neoplasms - secondary / Lymphatic Metastasis / Male / Medical and radiation oncology / Medicine/Public Health / Metastases / Metastasis / Middle Aged / Monoclonal antibodies / Mutation / Neutropenia / Neutropenia - chemically induced / Neutropenia - pathology / Neutropenia - prevention & control / Oncology / Oxaliplatin / Oxaliplatin - administration & dosage / Patients / Peritoneal Neoplasms - drug therapy / Peritoneal Neoplasms - secondary / Polyethylene glycol / Polyethylene glycol conjugated granulocyte colony-stimulating factor / Polyethylene Glycols - chemistry / Prevention / Prognosis / Research Article / Retrospective Studies / Solid tumors / Surgical Oncology / Survival / Survival Rate / Targeted cancer therapy / Terminology