Journal Article

The application of extracellular vesicles in colorectal cancer metastasis and drug resistance: recent advances and trends

Yuan, Jiyuan, Yin, Suyu, Pi, Chao, Zhao, Ling, Xiong, Linjin, Chen, Tao, Zhang, Xiaomei, Liu, Furong, Yang, Hongru, Chen, Jinglin, Liu, Huiyang, Tang, Jia, Wei, Yumeng, Jia, Qiang, Zuo, Ying

2023

Overview

Colorectal cancer (CRC) has high incidence and mortality rates and is one of the most common cancers of the digestive tract worldwide. Metastasis and drug resistance are the main causes of cancer treatment failure. Studies have recently suggested extracellular vesicles (EVs) as a novel mechanism for intercellular communication. They are vesicular particles, which are secreted and released into biological fluids, such as blood, urine, milk, etc., by a variety of cells and carry numerous biologically active molecules, including proteins, nucleic acids, lipids, metabolites, etc. EVs play a crucial part in the metastasis and drug resistance of CRC by delivering cargo to recipient cells and modulating their behavior. An in-depth exploration of EVs might facilitate a comprehensive understanding of the biological behavior of CRC metastasis and drug resistance, which might provide a basis for developing therapeutic strategies. Therefore, considering the specific biological properties of EVs, researchers have attempted to explore their potential as next-generation delivery systems. On the other hand, EVs have also been demonstrated as biomarkers for the prediction, diagnosis, and presumed prognosis of CRC. This review focuses on the role of EVs in regulating the metastasis and chemoresistance of CRC. Moreover, the clinical applications of EVs are also discussed. Graphical Abstract

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Angiogenesis / Biological activity / Biological properties / Biomarkers / Biomarkers - metabolism / Biosynthesis / Biotechnology / Cancer / Cell Communication / Cell organelles / Cells / Chemical properties / Chemistry / Chemistry and Materials Science / Chemoresistance / Colorectal cancer / Colorectal Neoplasms - metabolism / Drug delivery system / Drug delivery systems / Drug Resistance / Drug therapy / Drugs / Exploratory behavior / Extracellular vesicles / Extracellular Vesicles - metabolism / Fibroblasts / Gastrointestinal tract / Health aspects / Humans / Hypoxia / Lipid metabolism / Lipids / Metabolism / Metabolites / Metastases / Metastasis / Molecular Medicine / Mortality / Nanotechnology / Nucleic acids / Permeability / Pharmaceutical research / Proteins / Review / Telomerase / Vehicles / Vesicles