Journal Article

Interactions between microbiota and uterine corpus endometrial cancer: A bioinformatic investigation of potential immunotherapy

Almanaa, Taghreed N., Alkhalil, Samia S., Altamimi, Raghad A., El-Arabey, Amr Ahmed, Abdalla, Mohnad

2024

Overview

Microorganisms in the gut and other niches may contribute to carcinogenesis while also altering cancer immune surveillance and therapeutic response. However, determining the impact of genetic variations and interplay with intestinal microbes’ environment is difficult and unanswered. Here, we examined the frequency of thirteen mutant genes that caused aberrant gut in thirty different types of cancer using The Cancer Genomic Atlas (TCGA) database. Substantially, our findings show that all these mutated genes are quite frequent in uterine corpus endometrial cancer (UCEC). Further, these mutant genes are implicated in the infiltration of different subset of immune cells within the Tumor Microenvironment (TME) of UCEC patients. The top-ranking mutant genes that promote immune cell invasion into the TME of UCEC patients were PGLYRP2, OLFM4, and TLR5. In this regard, we used the same deconvolution of the TCGA database to analyze the microbiome that have a strong association with immune cells invasion with TME of UCEC patients. Several bacteria and viruses have been linked to the invasion of immune cells, such as B cell memory and T cell regulatory (Tregs), into the TME of UCEC patients. As a result, our findings pave the way for future research into generating novel immunizations against bacteria or viruses as immunotherapy for UCEC patients.

• Publisher: Public Library of Science
• Subject: Analysis / Bacteria / Bioinformatics / Biology and Life Sciences / Cancer / Carcinogenesis / Carcinogens / Care and treatment / Cells / Computational biology / Computational Biology - methods / Development and progression / Digestive system / Endometrial cancer / Endometrial Neoplasms - genetics / Endometrial Neoplasms - immunology / Endometrial Neoplasms - microbiology / Endometrium / Female / Gastrointestinal Microbiome - immunology / Gastrointestinal tract / Gene frequency / Gene mutations / Genes / Genetic aspects / Genetic diversity / Genetic engineering / Genotype & phenotype / Health aspects / Humans / Immune system / Immunological memory / Immunology / Immunosurveillance / Immunotherapy / Immunotherapy - methods / Influence / Investigations / Lymphocytes / Lymphocytes T / Medicine and Health Sciences / Memory cells / Metabolism / Metastases / Microbiomes / Microbiota / Microbiota (Symbiotic organisms) / Microbiota - immunology / Microorganisms / Mutants / Mutation / Ontology / Research and Analysis Methods / Risk factors / T cells / Testing / TLR5 protein / Toll-like receptors / Transgenic animals / Tumor microenvironment / Tumor Microenvironment - immunology / Uterine cancer / Uterus