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Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways
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Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways
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Journal Article
Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways
2016
Overview
A major cause of preterm labor in pregnant women is intra-amniotic infection, which is mediated by an inflammatory process. Hydrogen sulfide (H2S), a gaseous transmitter, has been implicated to be involved in inflammatory responses. We sought to investigate whether H2S affects infectious preterm birth using the mouse model of lipopolysaccharides (LPS)-induced preterm birth. Administration of LPS at 0.4 mg/kg with two injections intraperitoneally (i.p.) on gestational day 14.5 induced preterm labor. LPS significantly increased leukocyte infiltration in uterus, stimulated the expression of pro-inflammatory cytokines interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), CCL2 and CXCL15 in myometrium. Administration of NaHS (i.p.) delayed the onset of labor induced by LPS in a dose-dependent manner. NaHS prevented leukocyte infiltration into intrauterine tissues and inhibited the production of pro-inflammatory cytokines in myometrium and decreased the levels of these cytokines in maternal circulation. H2S also decreased LPS-activated extracellular signal-regulated kinase (ERK) 1/2/ nuclear factor (NF)-κB signaling pathways in myometrium. This study provides new in vivo evidence for the roles of H2S in attenuating inflammation, and a potential novel therapeutic strategy for infection-related preterm labor.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Birth
/ E coli
/ Extracellular signal-regulated kinase
/ Female
/ Hydrogen
/ Hydrogen Sulfide - pharmacology
/ Inflammation Mediators - metabolism
/ Kinases
/ Labor
/ Lipopolysaccharides - pharmacology
/ Medicine and Health Sciences
/ Mice
/ Monocyte chemoattractant protein 1
/ Obstetric Labor, Premature - chemically induced
/ Research and Analysis Methods
/ Rodents
/ Studies
/ Sulfide
/ Sulfides
/ Tissues
/ Uterus
