Journal Article

Risk factors for bronchiolitis hospitalization in infants: A French nationwide retrospective cohort study over four consecutive seasons (2009-2013)

Développement, Adaptation et Handicap (DevAH) ; Université de Lorraine (UL), Translational Health Economics Network [Paris] (THEN), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, The present study was supported by AbbVie France. Translational Health Economics (THEN) was responsible for data collection, preparation, and validation with external sources of information. THEN received payment from AbbVie for these activities. Writing charges were funded by AbbVie France, and AbbVie approved the decision to submit the paper for publication, but the corresponding author was ultimately responsible for submitting the manuscript for publication, Maternité Régionale Adolphe Pinard [Nancy], Magny, Jean-François, Physiopathologie des Adaptations Nutritionnelles (PhAN) ; Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECI

2020

Overview

Objectives: Large studies are needed to update risk factors of bronchiolitis hospitalization. We performed a nationwide analysis of hospitalization rates for bronchiolitis over four consecutive bronchiolitis seasons to identify underlying medical disorders at risk of bronchiolitis hospitalization and assess their frequency.Methods: Data were retrieved from the French National Hospital Discharge database. Of all infants discharged alive from maternity wards from January 2008 to December 2013 in France (N = 3,884,791), we identified four consecutive cohorts at risk of bronchiolitis during the seasons of 2009–2010 to 2012–2013. The main outcome was bronchiolitis hospitalization during a season. Individual risk factors were collected.Results: Among infants, 6.0% were preterm and 2.0% had ≥1 chronic condition including 0.2% bronchopulmonary dysplasia (BPD) and 0.2% hemodynamically significant congenital heart disease (HS-CHD). Bronchiolitis hospitalization rates varied between seasons (min: 1.26% in 2010–2011; max: 1.48% in 2012–2013; p<0.001). Except omphalocele, the following conditions were associated with an increased risk for bronchiolitis hospitalization: solid organ (9.052; 95% CI, 4.664–17.567) and stem cell transplants (6.012; 95% CI, 3.441–10.503), muscular dystrophy (4.002; 95% CI, 3.1095–5.152), cardiomyopathy (3.407; 95% CI, 2.613–4.442), HS-CHD (3.404; 95% CI, 3.153–3.675), congenital lung disease and/or bronchial abnormalities, Down syndrome, congenital tracheoesophageal fistula, diaphragmatic hernia, pulmonary hypertension, chromosomal abnormalities other than Down syndrome, hemodynamically non-significant CHD, congenital abnormalities of nervous system, cystic fibrosis, cleft palate, cardiovascular disease occurring during perinatal period, and BPD.Conclusion: Besides prematurity, BPD, and HS–CHD, eighteen underlying conditions were associated with a significant increased risk for bronchiolitis hospitalization in a nationwide population.

• Publisher: CCSD,Public Library of Science,Public Library of Science (PLoS)
• Subject: [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases / [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics / [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract / [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie / Abnormalities / Age / Biology and Life Sciences / Birth weight / Bronchiolitis / Bronchopneumonia / Bronchopulmonary dysplasia / Cardiomyopathy / Cardiovascular disease / Cardiovascular diseases / Chromosome aberrations / Chronic illnesses / Cleft lip/palate / Cleft palate / Codes / Cohort analysis / Comorbidity / Congenital diseases / Congenital heart defects / Coronary artery disease / Cystic fibrosis / Diaphragmatic hernia / Discharge / Diseases / Down syndrome / Down's syndrome / Dysplasia / Dystrophy / Female / Fibrosis / Fistulae / Fistulas / France / Genetic disorders / Health risks / Heart diseases / Hernia / Hospital admission and discharge / Hospitalization / Hospitals / Human health and pathology / Humans / Hydrologic data / Hypertension / Infant / Infants / Infections / Infectious diseases / Intensive care / Life Sciences / Lung diseases / Male / Medical research / Medicine / Medicine and Health Sciences / Multiple births / Muscular dystrophy / Myocardial diseases / Nervous system / Neuromuscular diseases / Newborn babies / Pediatrics / People and Places / Pharmaceutical industry / Population / Pulmonary hypertension / Pulmonology and respiratory tract / Q / R / Research Article / Respiratory syncytial virus / Respiratory tract diseases / Risk analysis / Risk factors / Santé publique et épidémiologie / Science / Seasons / Stem cell transplantation / Stem cells / Tracheoesophageal fistula / Transplants / Viral infections / Viruses