Journal Article

Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings

Zhang, Qiaojian, Zheng, Shufang, Xu, Shiwen, Zhu, Fating, Xue, Hua, Xing, Houjuan

2019

Overview

Selenium (Se) is an essential trace element for humans and animals. Appropriate amount of Se in the body can prevent a variety of diseases. However, Se deficiency leads to pathological changes such as skeletal muscle necrosis and pancreatic atrophy in livestock and poultry. Se preparations are widely used in the prevention and treatment of Se-deficient disease, but there is no unified standard of medication, and the safe dose range of Se is narrow. Therefore, it is of great significance to study the pharmacokinetics of low-Se ducklings and to formulate drug administration schemes. In the present study, eighty 1-day-old healthy ducklings were randomly selected, and fed with low-Se diet to 30 days of age (blood Se content ≦ 0.03 μg/mL). After the low Se duckling models were duplicated, blood samples and tissues of livers, pancreases, and thigh muscles were collected at different time points to detect Se content following oral administration of 0.1% sodium selenite (Na 2 SeO 3 ) at 0.8 mg/kg BW, and the pharmacokinetics parameters were automatically calculated by MCPKP program. The results showed that pharmacokinetics characteristics of Na 2 SeO 3 in blood, livers, and pancreases of ducklings were consistent with the first-order absorption and two-compartment open models; in thigh muscles was consistent with the first-order absorption and one compartment with a lag time open model. The primary kinetic parameters of Na 2 SeO 3 in blood: the half-life of absorption was 5.9026 h, the time of reaching maximum concentration was 23.03 h, and the half-life of elimination was 131.13 h. The absorption of Na 2 SeO 3 in livers was the quickest, pancreases and thigh muscles were in order of becoming slower, and the elimination of Na 2 SeO 3 in thigh muscles was the quickest, livers and pancreases were in order of becoming slower. The administration parameters of multi-dose were calculated according to the kinetic of single-dose: loading dose (D*) was 1.7046 mg/kg BW, maintenance dose (D 0 ) was 0.8 mg/kg BW, and dosing interval (τ) was 120 h. The results of this study can supplement and improve the theoretical system of Se metabolic kinetics, and provide experimental basis for the prevention and treatment of Se deficiency disease by rational drug use.

• Publisher: Springer US,Springer Nature B.V
• Subject: Absorption / Administration, Oral / animal models / Animals / Atrophy / Biochemistry / Biomedical and Life Sciences / Biotechnology / Blood / blood sampling / Chemical kinetics / Deficiency diseases / diet / Dose-Response Relationship, Drug / Drug dosages / Drug therapy / Drugs / ducklings / Ducks / Female / Half-life / humans / Juveniles / Kinetics / Lag time / Life Sciences / liver / Liver - chemistry / Livestock / Male / Mathematical models / Muscles / Muscles - chemistry / Necrosis / nutrient deficiencies / Nutrient deficiency / Nutrition / Oncology / Oral administration / Pancreas / Pancrelipase - chemistry / Parameters / Pharmacokinetics / Pharmacology / Prevention / Reaction kinetics / Selenium / Selenium - blood / Selenium - deficiency / Skeletal muscle / Sodium / Sodium selenite / Sodium Selenite - administration & dosage / Sodium Selenite - blood / Sodium Selenite - pharmacokinetics / Thigh / Tissue / Tissue Distribution / Trace elements