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Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

by Lin, Zhen , Yang, Dehong , Ma, Xueming , Hu, Shaoyu , Liu, Yi , Zhang, Jiawei , Wu, Qian , Zhu, Siyuan , Ye, Wenbin , Jiang, Jianming , Qu, Dongbin

in 14/19 / 140/131 / 631/67/1059/602 / 631/67/1347 / 631/67/322/803 / 64/60 / Ablation / Animals / Bone cancer / Bone Neoplasms - secondary / Bone Neoplasms - therapy / Breast cancer / Breast Neoplasms - pathology / Cell Line, Tumor / Cell Survival - drug effects / Female / Humanities and Social Sciences / Humans / I.R. radiation / Infrared Rays / Irradiation / Lasers / MCF-7 Cells / Metastases / Metastasis / Mice / Mice, Inbred BALB C / multidisciplinary / Nanotechnology / Nanotubes / Nanotubes, Carbon - chemistry / Nanotubes, Carbon - toxicity / Phototherapy / Polyethylene Glycols - chemistry / Science / Temperature / Temperature effects / Toxicity / X-Ray Microtomography / Xenograft Model Antitumor Assays / Xenografts

2015

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Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

by Lin, Zhen , Yang, Dehong , Ma, Xueming , Hu, Shaoyu , Liu, Yi , Zhang, Jiawei , Wu, Qian , Zhu, Siyuan , Ye, Wenbin , Jiang, Jianming , Qu, Dongbin

2015

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Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

by Lin, Zhen , Yang, Dehong , Ma, Xueming , Hu, Shaoyu , Liu, Yi , Zhang, Jiawei , Wu, Qian , Zhu, Siyuan , Ye, Wenbin , Jiang, Jianming , Qu, Dongbin

2015

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Journal Article

Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

Lin, Zhen,

Yang, Dehong,

Ma, Xueming,

Hu, Shaoyu,

Liu, Yi,

Zhang, Jiawei,

Wu, Qian,

Zhu, Siyuan,

Ye, Wenbin,

Jiang, Jianming,

Qu, Dongbin

2015

Overview

This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted in a rapid heat generation which increased with the MWNTs concentration up to 100 μg/ml. MWNTs alone exhibited no toxicity, but inclusion of MWNTs dramatically decreased cell viability when combined with laser irradiation. Thermographic observation revealed that treatment with 10 μg MWNTs followed by NIR laser irradiation resulted in a rapid increase in temperature up to 73.4±11.98 °C in an intraosseous model of bone metastasis of breast cancer. In addition, MWNTs plus NIR laser irradiation caused a remarkably greater suppression of tumor growth compared with treatment with either MWNTs injection or NIR irradiation alone, significantly reducing the amount of tumor-induced bone destruction. All these demonstrate the efficacy of PTT with MWNTs for bone metastasis of breast cancer.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 140/131

/ 64/60