Journal Article

Polycyclic Aromatic Hydrocarbons (PAHs) in the Environment: Occupational Exposure, Health Risks and Fertility Implications

Pinto, Gabriella, Spinelli, Michele, Esposito, Gennaro, Motta, Oriana, Sofia, Daniele, Gallo, Pasquale, Piscopo, Marina, Amoresano, Angela, Baldini, Giorgio Maria, Ricciardi, Maria, Carati, Cosimo, Brogna, Carlo, Montano, Luigi, Palmieri, Ilaria, Fontanarosa, Carolina, Esposito, Mauro, Liguori, Giovanna, Lombardi, Renato

2025

Overview

Polycyclic aromatic hydrocarbons (PAHs) are a group of organic compounds with fused aromatic rings, primarily derived from combustion processes and environmental pollutants. This narrative review discusses the most relevant studies on PAHs, focusing on their sources, environmental and occupational exposure, and effects on human health, emphasizing their roles as carcinogenic, mutagenic, and teratogenic agents. The primary pathways for human exposure to PAHs are through the ingestion of contaminated food (mainly due to some food processing methods, such as smoking and high-temperature cooking techniques), the inhalation of ambient air, and the smoking of cigarettes. Coke oven workers are recognized as a high-risk occupational group for PAH exposure, highlighting the need for appropriate strategies to mitigate these risks and safeguard worker health. PAHs are metabolized into reactive intermediates in the body, which can lead to DNA damage and promote the development of various health conditions, particularly in environments with high exposure levels. Chronic PAH exposure has been linked to respiratory diseases, as well as cardiovascular problems and immune system suppression. Furthermore, this review underscores the significant impact of PAHs on reproductive health. The results of the reported studies suggest that both male and female fertility can be compromised due to oxidative stress, DNA damage, and endocrine disruption caused by PAH exposure. In males, PAHs impair sperm quality, while, in females, they disrupt ovarian function, potentially leading to infertility, miscarriage, and birth defects. Fetal exposure to PAHs is also associated with neurodevelopmental disorders. Given the extensive and detrimental health risks posed by PAHs, this review stresses the importance of stringent environmental regulations, occupational safety measures, and public health initiatives to mitigate exposure and safeguard reproductive and overall health.

• Publisher: MDPI AG,MDPI
• Subject: Air temperature / Animals / Aquifers / Aromatic compounds / Bacteria / Bioaccumulation / bioaccumulation and metabolization / Bioremediation / Birth defects / Carcinogens / Cigarettes / Coke ovens / Combustion / Congenital defects / Damage / Deoxyribonucleic acid / DNA / DNA damage / Endocrine disruptors / environment / Environmental regulations / Enzymes / Exposure / Females / Fertility / Fetuses / Food contamination / Food contamination & poisoning / Food processing / Fungi / Health / Health aspects / health effects / Health promotion / Health risk assessment / Health risks / High temperature / Immune system / Infertility / Ingestion / Inhalation / Intermediates / Microbiota / Microorganisms / Molecular weight / Neurodevelopmental disorders / Occupational exposure / Occupational health / Occupational health and safety / Occupational safety / Organic compounds / Oxidation / Oxidative stress / Pollutants / Polycyclic aromatic hydrocarbons / Prenatal exposure / Public health / Reproductive health / Reproductive status / Respiration / Respiratory diseases / Review / Safety measures / Smoking / Soil fertility / Teratogenicity / Toxicity