Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

by Heymann, Jurgen , Thanai, Paxton , Saito, Ritsumi , Matsuo, Akihiro , Oikawa, Yoshitsugu , Fukuda, Noriko N. , Fukuda, Shinji , Akiyama, Yukako , Ogawa, Susumu , Suzuki, Naoto , Kikuchi, Koichi , Nakamura, Tomohiro , Asaji, Kei , Yamamoto, Masayuki , Kure, Shigeo , Ogata, Yoshiaki , Nagao, Shizuko , Suzuki, Takashi , Ichijo, Mariko , Mukawa, Chikahisa , Shimizu, Miho , Ito, Sadayoshi , Kopp, Jeffrey B. , Oe, Yuji , Sato, Toshihiro , Akiyama, Yasutoshi , Mano, Nariyasu , Wada, Takashi , Soga, Tomoyoshi , Mise, Koki , Iwasaki, Tomoyuki , Kanemitsu, Yoshitomi , Hozawa, Atsushi , Yamaguchi, Hiroaki , Takahashi, Nobuyuki , Tomioka, Yoshihisa , Matsuhashi, Tetsuro , Ogura, Jiro , Suzuki, Chitose , Toyohara, Takafumi , Owada, Yuji , Tsukamoto, Hiroki , Breeggemann, Matthew C. , Tsukimi, Tomoya , Shimada, Satoshi , Suzuki, Takehiro , Yang, Ching-Chin , Abe, Takaaki , Matsumoto, Yotaro , Wada, Jun , Saigusa, Daisuke , Ohsaki, Yusuke , HO, Hsin-Jung , Nanto-Hara, Fumika , Shima, Hisato , Mishima, Eikan

in 14 / 38 / 42 / 45 / 49 / 631/326/2565/2134 / 631/443/319/320 / 64/110 / 64/86 / 692/4022/1585/2759/1419 / 82/16 / 82/58 / 96 / Adult / Aged / Aged, 80 and over / Albuminuria - blood / Albuminuria - drug therapy / Albuminuria - etiology / Albuminuria - pathology / Animals / Animals, Genetically Modified / Cohort Studies / Diabetes / Diabetes mellitus / Diabetes Mellitus, Experimental - blood / Diabetes Mellitus, Experimental - chemically induced / Diabetes Mellitus, Experimental - complications / Diabetes Mellitus, Experimental - urine / Diabetes Mellitus, Type 1 - blood / Diabetes Mellitus, Type 1 - complications / Diabetes Mellitus, Type 2 - blood / Diabetes Mellitus, Type 2 - complications / Diabetic Nephropathies - blood / Diabetic Nephropathies - etiology / Diabetic Nephropathies - pathology / Diabetic nephropathy / Digestive system / Dogs / Enzyme Inhibitors - pharmacology / Enzyme Inhibitors - therapeutic use / Female / Gastrointestinal Microbiome - physiology / Gut microbiota / Humanities and Social Sciences / Humans / Intestinal microflora / Kidney diseases / Kidneys / Madin Darby Canine Kidney Cells / Male / Markers / Metabolites / Metabolomics / Metabolomics - methods / Mice / Mice, Inbred C57BL / Microbiomes / Microbiota / Middle Aged / multidisciplinary / Organic Anion Transporters - genetics / Phenols / Podocytes - metabolism / Podocytes - pathology / Proteinuria / Rats / Renal failure / Science / Science (multidisciplinary) / Streptozocin - toxicity / Sulfates / Sulfuric Acid Esters - blood / Sulfuric Acid Esters - metabolism / Therapeutic applications / Toxins / Tyrosine / Tyrosine phenol-lyase / Tyrosine Phenol-Lyase - antagonists & inhibitors / Tyrosine Phenol-Lyase - metabolism / Young Adult

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

2019

Confirm

Do you wish to request the book?

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Heymann, Jurgen,

Thanai, Paxton,

Saito, Ritsumi,

Matsuo, Akihiro,

Oikawa, Yoshitsugu,

Fukuda, Noriko N.,

Fukuda, Shinji,

Akiyama, Yukako,

Ogawa, Susumu,

Suzuki, Naoto,

Kikuchi, Koichi,

Nakamura, Tomohiro,

Asaji, Kei,

Yamamoto, Masayuki,

Kure, Shigeo,

Ogata, Yoshiaki,

Nagao, Shizuko,

Suzuki, Takashi,

Ichijo, Mariko,

Mukawa, Chikahisa,

Shimizu, Miho,

Ito, Sadayoshi,

Kopp, Jeffrey B.,

Oe, Yuji,

Sato, Toshihiro,

Akiyama, Yasutoshi,

Mano, Nariyasu,

Wada, Takashi,

Soga, Tomoyoshi,

Mise, Koki,

Iwasaki, Tomoyuki,

Kanemitsu, Yoshitomi,

Hozawa, Atsushi,

Yamaguchi, Hiroaki,

Takahashi, Nobuyuki,

Tomioka, Yoshihisa,

Matsuhashi, Tetsuro,

Ogura, Jiro,

Suzuki, Chitose,

Toyohara, Takafumi,

Owada, Yuji,

Tsukamoto, Hiroki,

Breeggemann, Matthew C.,

Tsukimi, Tomoya,

Shimada, Satoshi,

Suzuki, Takehiro,

Yang, Ching-Chin,

Abe, Takaaki,

Matsumoto, Yotaro,

Wada, Jun,

Saigusa, Daisuke,

Ohsaki, Yusuke,

HO, Hsin-Jung,

Nanto-Hara, Fumika,

Shima, Hisato,

Mishima, Eikan

2019

Overview

Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. In a diabetic patient cohort, phenyl sulfate levels significantly correlate with basal and predicted 2-year progression of albuminuria in patients with microalbuminuria. Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. Together, our results suggest that phenyl sulfate contributes to albuminuria and could be used as a disease marker and future therapeutic target in diabetic kidney disease. Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 38

/ 42

/ 45

/ 49

/ 631/326/2565/2134

/ 631/443/319/320

/ 64/110