Asset Details
Do you wish to reserve the book?
A metastasis map of human cancer cell lines
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A metastasis map of human cancer cell lines
Do you wish to request the book?
A metastasis map of human cancer cell lines
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A metastasis map of human cancer cell lines
2020
Overview
Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical owing to the complexity of in vivo models. Here we introduce an in vivo barcoding strategy that is capable of determining the metastatic potential of human cancer cell lines in mouse xenografts at scale. We validated the robustness, scalability and reproducibility of the method and applied it to 500 cell lines
1
,
2
spanning 21 types of solid tumour. We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features. We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain—a principal cause of death in patients with this type of cancer. Breast cancers capable of metastasizing to the brain showed evidence of altered lipid metabolism. Perturbation of lipid metabolism in these cells curbed brain metastasis development, suggesting a therapeutic strategy to combat the disease and demonstrating the utility of MetMap as a resource to support metastasis research.
A method in which pooled barcoded human cancer cell lines are injected into a mouse xenograft model enables simultaneous mapping of the metastatic potential of multiple cell lines, and shows that breast cancer cells that metastasize to the brain have altered lipid metabolism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/39
/ 38/47
/ 38/5
/ 38/77
/ 64/60
/ Analysis
/ Animals
/ Brain
/ Brain Neoplasms - metabolism
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Cancer
/ Female
/ Humanities and Social Sciences
/ Humans
/ Lipids
/ Methods
/ Mice
/ Mutation
/ Neoplasm Metastasis - genetics
/ Neoplasm Metastasis - pathology
/ Science
/ Tumors
We currently cannot retrieve any items related to this title. Kindly check back at a later time.