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ILC2-derived LIF licences progress from tissue to systemic immunity
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Journal Article
ILC2-derived LIF licences progress from tissue to systemic immunity
2024
Overview
Migration and homing of immune cells are critical for immune surveillance. Trafficking is mediated by combinations of adhesion and chemokine receptors that guide immune cells, in response to chemokine signals, to specific locations within tissues and the lymphatic system to support tissue-localized immune reactions and systemic immunity
1
,
2
. Here we show that disruption of leukaemia inhibitory factor (LIF) production from group 2 innate lymphoid cells (ILC2s) prevents immune cells leaving the lungs to migrate to the lymph nodes (LNs). In the absence of LIF, viral infection leads to plasmacytoid dendritic cells (pDCs) becoming retained in the lungs where they improve tissue-localized, antiviral immunity, whereas chronic pulmonary allergen challenge leads to marked immune cell accumulation and the formation of tertiary lymphoid structures in the lung. In both cases immune cells fail to migrate to the lymphatics, leading to highly compromised LN reactions. Mechanistically, ILC2-derived LIF induces the production of the chemokine CCL21 from lymphatic endothelial cells lining the pulmonary lymphatic vessels, thus licensing the homing of CCR7
+
immune cells (including dendritic cells) to LNs. Consequently, ILC2-derived LIF dictates the egress of immune cells from the lungs to regulate tissue-localized versus systemic immunity and the balance between allergen and viral responsiveness in the lungs.
Disruption of leukaemia inhibitory factor production from group 2 innate lymphoid cells prevents immune cells leaving the lungs to migrate to lymph nodes, leading to plasmacytoid dendritic cells becoming retained in the lungs following viral infection.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/21
/ 13/31
/ 42
/ 45
/ 45/91
/ 64
/ 64/110
/ Animals
/ Chemokine CCL21 - immunology
/ Chemokine CCL21 - metabolism
/ Dendritic Cells - immunology
/ Endothelial Cells - immunology
/ Female
/ Homing
/ Humanities and Social Sciences
/ Immunity
/ Immunity, Innate - immunology
/ Leukemia
/ Leukemia Inhibitory Factor - immunology
/ Leukemia Inhibitory Factor - metabolism
/ Lungs
/ Lymphatic Vessels - immunology
/ Male
/ Mice
/ Receptors, CCR7 - immunology
/ Receptors, CCR7 - metabolism
/ Science
/ Tissues
/ Viruses
