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Effects of the obese gene product on body weight regulation in ob/ob mice
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Effects of the obese gene product on body weight regulation in ob/ob mice
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Journal Article
Effects of the obese gene product on body weight regulation in ob/ob mice
1995
Overview
C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob/ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Adipose Tissue - drug effects
/ analysis
/ Animals
/ Biological and medical sciences
/ blood
/ Body Composition - drug effects
/ Body fat
/ Body Temperature - drug effects
/ Classical genetics, quantitative genetics, hybrids
/ Climate
/ Dosage
/ Dose-Response Relationship, Drug
/ Drinking
/ Eating
/ Energy Metabolism - drug effects
/ Female
/ Fundamental and applied biological sciences. Psychology
/ GENE
/ GENES
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ GLUCOSA
/ GLUCOSE
/ Insulin
/ INSULINA
/ INSULINE
/ Leptin
/ Mice
/ Motor Activity - drug effects
/ Mutation
/ Obesity
/ Oxygen Consumption - drug effects
/ PESO
/ POIDS
/ PROTEINE
/ Proteins
/ RATON
/ Recombinant Proteins - pharmacology
/ Rodents
/ SOURIS
/ SURPOIDS
/ Water
